نتایج جستجو برای: hnf4a
تعداد نتایج: 457 فیلتر نتایج به سال:
Maturity-onset diabetes of the young (MODY; MIM# 606391) is a genetically and clinically heterogeneous form of diabetes, accounting for 1–2% of all diabetes cases (1). MODY is characterized by mild hyperglycemia or overt diabetes usually detected in three consecutive generations, with onset before the age of 25 years and absence of type 1 diabetes autoantibodies. Among the thirteen MODY genes i...
Insulin is the major hormone that regulates hepatic glucose metabolism by repressing gluconeogenic enzyme-encoding genes, and the counteracting glucagon/protein kinase (PKA)–inducible coactivating peroxisome proliferator– activated receptor g coactivator-1a (PGC-1a) signaling pathway is also well characterized in hepatic glucose metabolism (1–3). Until now, however, the regulation of the insuli...
Monogenic diabetes characteristics in a transnational multicenter study from Mediterranean countries
Abstract Background Diagnosis of monogenic diabetes has important clinical implications for treatment and health expenditure. However, its prevalence remains to be specified in many countries, particularly from South Europe, North Africa Middle-East, where non-autoimmune young adults is increasing dramatically. Aims To identify cases Mediterranean countries assess the specificities between coun...
The availability of pluripotent stem cells offers the possibility of using such cells to model hepatic disease and development. With this in mind, we previously established a protocol that facilitates the differentiation of both human embryonic stem cells and induced pluripotent stem cells into cells that share many characteristics with hepatocytes. The use of highly defined culture conditions ...
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