Disruption of ephrin B1 in collagen I producing cells in mice results in severe skull defects and reduced bone formation. Because ephrin B1 is also expressed during osteoclast differentiation and because little is known on the role of ephrin B1 reverse signaling in bone resorption, we examined the bone phenotypes in ephrin B1 conditional knockout mice, and studied the function of ephrin B1 reve...

5,258,947 A * 1111993 Sourgen ...................... 365196 5,677,691 A * 1011997 Hosticka et al. .............. 326139 5,705,938 A * 111998 Kean ........................... 326139 5,959,871 A * 911999 Pierzchala et al. .......... 3271565 5,970,487 A * 1011999 Shackleford et al. ......... 706113 6,360,191 B1 * 312002 Koza et al. ................... 703114 6,363,517 B1 * 312002 Levi et al. ........

The mammalian nuclear lamina protein lamin B1 is posttranslationally modified by farnesylation, endoproteolysis, and carboxymethylation at a carboxyl-terminal CAAX motif. In this work, we demonstrate that the CAAX endoprotease Rce1 is required for lamin B1 endoproteolysis, demonstrate an independent pool of proteolyzed but nonmethylated lamin B1, as well as fully processed lamin B1, in interpha...

We report that a fatty acyl transferase, endophilin B1, is required for maintenance of mitochondrial morphology. Down-regulation of this protein or overexpression of endophilin B1 lacking the NH(2)-terminal lipid-modifying domain causes striking alterations of the mitochondrial distribution and morphology. Dissociation of the outer mitochondrial membrane compartment from that of the matrix, and...

Abstract. Let B1 be the unit open disk in R2 and M be a closed Riemannian manifold. In this note, we first prove the uniqueness for weak solutions of the harmonic map heat flow in H1([0, T ]×B1,M) whose energy is non-increasing in time, given initial data u0 ∈ H(B1,M) and boundary data γ = u0|∂B1 . Previously, this uniqueness result was obtained by Rivière (when M is the round sphere and the en...

Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. The MIT Faculty has made this article openly available. Please share how this access benefits you. Your story matters. Self-assembling peptide hydrogels were modified to deliver transforming growth factor b1 (TGF-b1) to encapsulated b...