Patients with HIV infection may develop common diseases with atypical clinical features. HIV infection may change the classic clinical course of syphilis and increase the incidence of a subtype of secondary syphilis named malignant syphilis. A homosexual patient with HIV infection consulted us about a one-month history of general malaise and widespread cutaneous ulcerative lesions, some with th...

Although human intervertebral disc degeneration can lead to several spinal diseases, its pathogenesis remains unclear. This study aimed to create a new histological classification applicable to an in vivo mouse intervertebral disc degeneration model induced by needle puncture. One hundred six mice were operated and the L4/5 intervertebral disc was punctured with a 35- or 33-gauge needle. Micro-...

changes here described from the appearance of secondary neoplasm, particularly neuroblastoma, may be difficult, and the diagnosis may only become clear with evolution of more typical radiological appearances. Eversole, Holman, and Robinson in 1957 described focal resorption of cortical bone as an early microscopical feature in the evolution of infantile cortical hyperostosis. The relative vascu...

HCV RNA levels were measured in patients with chronic hepatitis C (Cobas Amplicor HCV Monitor v2.0). Liver biopsies were obtained at baseline and after 12 months of treatment and were read independently by two hepatopathologists who were blinded to the biopsy sequence. Modified Histological Activity (HAI) Index of Knodell and Ishak fibrosis stage were used to assess changes in necroinflammatory...

Prediction of the histology of MPGN was performed without doing a renal biopsy by a univariate and multivariate analysis of three histological groups in nephrotic children: membranoproliferative glomerulonephritis (MPGN, N=13), proliferative glomerulonephritis (PGN, N=11) and minimal change nephrotic syndrome (MCNS, N=10). If the Y value of the following equation exceeded 0.41, the probability ...

Introduction: Multi-echo T2 relaxation allows scientists to probe water micro-compartments in vivo [1]. T2 relaxation is sensitive to myelin content [2] and has uncovered previously undetected micro-compartments in MS and PKU pathological tissue [3]. We aim to characterize how T2 distributions of fixed brain change with different types of MS pathology, identified using ex vivo histological stai...