A key role for histamine in the physiological control of gastric acid secretion was established with the advent of the histamine H2-receptor antagonists which have in vivo been shown to inhibit virtually all forms of basal and stimulated secretion.' These data can be seen to support the common mediator hypothesis championed in the last three decades by Code2 3 and which states that secretory st...

A key role for histamine in the physiological control of gastric acid secretion was established with the advent of the histamine H2-receptor antagonists which have in vivo been shown to inhibit virtually all forms of basal and stimulated secretion.' These data can be seen to support the common mediator hypothesis championed in the last three decades by Code2 3 and which states that secretory st...

Eosinophils are essential inflammatory cells in the pathogenesis of asthma and atopic conditions. Histamine, released from mast cells and basophils in response to allergen exposure, is a critical mediator in the allergic response. Histamine exerts its effects via four unequivocally characterized histamine receptors, H(1-4). Several functions of eosinophils have previously been shown to be stimu...

A key role for histamine in the physiological control of gastric acid secretion was established with the advent of the histamine H2-receptor antagonists which have in vivo been shown to inhibit virtually all forms of basal and stimulated secretion.' These data can be seen to support the common mediator hypothesis championed in the last three decades by Code2 3 and which states that secretory st...

A key role for histamine in the physiological control of gastric acid secretion was established with the advent of the histamine H2-receptor antagonists which have in vivo been shown to inhibit virtually all forms of basal and stimulated secretion.' These data can be seen to support the common mediator hypothesis championed in the last three decades by Code2 3 and which states that secretory st...

Mammalian retinas are innervated by histaminergic axons that originate from perikarya in the posterior hypothalamus. To identify the targets of these retinopetal axons, we localized histamine receptors (HR) in monkey and rat retinas by light and electron microscopy. In monkeys, puncta containing HR3 were found at the tips of ON-bipolar cell dendrites in cone pedicles and rod spherules, closer t...

Despite the recognized importance of the dorsal raphe (DR) serotonergic (5-HT) nuclei in the pathophysiology of depression and anxiety, the molecular components/putative drug targets expressed by these neurons are poorly characterized. Utilizing the promoter of an ETS domain transcription factor that is a stable marker of 5-HT neurons (Pet-1) to drive 5-HT neuronal expression of YFP, we identif...

Excessive accumulation of histamine in the body leads to miscellaneous symptoms mediated by its bond to corresponding receptors (H1-H4). Increased concentration of histamine in blood can occur in healthy individuals after ingestion of foods with high contents of histamine, leading to histamine intoxication. In individuals with histamine intolerance (HIT) ingestion of food with normal contents o...