BACKGROUND Adrenomedullin is a hypotensive peptide recently discovered in human phaeochromocytoma which has been found to inhibit bronchoconstriction induced by histamine and acetylcholine. This study was designed to determine the manner in which adrenomedullin and other bronchodilators interact in modulating airway function. METHODS A study was undertaken to determine whether adrenomedullin ...

Histamine is present in high concentrations in the intestine and we investigated the possibility that it might have a role here in intestinal transport. When added to the basal side of rabbit ileal mucosa in vitro histamine (10(-4)M) induced a short-lived increase in electrical potential difference and short circuit current. It inhibited net chloride absorption but did not influence sodium tran...

M OST OF THE HISTAMINE of human blood is found iii the buffy coat.2 ‘ Earlier attempts to identify the histamine-carrying constituent of this leukocyte-platelet layer have been unsuccessful.4 Because human platelets, lymphocytes in lymph nodes, amid momiocytes from exudates have all been found to contain little histamimie, amid because blood histamine remains normal imi pathological conditions ...

Diamine oxidase (DAO) is abundantly expressed in mammalian small intestine catalyzing the oxidative breakdown of polyamines and histamine. The aim of this study was to determine the relationship between stimulation of intestinal diamine oxidase secretion with intestinal fat absorption and histamine release. Conscious intestinal lymph fistula rats were used. The mesenteric lymph ducts were cannu...

Some marine invertebrate larvae expand the range of settlement cues to which they will respond as they age. How do relatively simple larvae achieve such complex changes in behaviour? Larvae of the Australian sea urchin Holopneustes purpurascens settle and metamorphose specifically in response to a settlement cue, dissolved histamine, produced by the host alga Delisea pulchra. Older H. purpurasc...

WOODS, JAMES R., JR., C. R. BRINKMAN, III, A. DANDAVINO, K. MURAYAMA, AND N. S. ASSALI. Action of histamine and H, and H, blockers on the cardiopulmonary circulation. Am. J. Physiol. 232(l): H73-H78, 1977 or Am. J. Physiol.: Heart Circ. Physiol. l(1): H73-H78, 1977. -Systemic and pulmonary hemodynamic responses to histamine were investigated in chronically instrumented unanesthetized nonpregnan...

Bioactive amines are low molecular weight organic bases, formed by biological processes in all living organisms. One such bioactive amine is histamine. Wine, particularly red wine, is a beverage that contains significant amounts of histamine. Although there are many agents in red wine known to cause headaches (e.g. ethanol), histamine has been identified as the primary cause for intense headach...

Experimental solutions known to affect mast cells or to cause liberation of histamine from the tissue were introduced into the peritoneal cavity of rats. Samples of the peritoneal fluid were withdrawn at intervals afterward and assayed for histamine and the condition of the mast cells was subsequently ascertained by microscopic examination of stained spreads of the mesenteries. Intraperitoneal ...

Pharmacological studies in mammals and zebrafish suggest that histamine plays an important role in promoting arousal. However, genetic studies using rodents with disrupted histamine synthesis or signaling have revealed only subtle or no sleep/wake phenotypes. Studies of histamine function in mammalian arousal are complicated by its production in cells of the immune system and its roles in humor...

PURPOSE Previously, retinopetal axons containing histamine and dopaminergic neurons expressing histamine H(1)-receptor had been localized in mouse retinas using anatomic techniques. The goal of these experiments was to demonstrate that these receptors are functional. METHODS Dopaminergic cells were acutely isolated from retinas of transgenic mice expressing red fluorescent protein under contr...