As a structural component of the outer membrane of Gram-negative bacteria, endotoxin, also known as lipopolysaccharide (LPS) exhibits strong immunostimulatory properties, rendering it a pivotal role in the pathogenesis of Gram-negative septicaemia. Our attempt to identify LPS-binding proteins from the hemolymph of the horseshoe crab led to the isolation and identification of Creactive protein (...

Purpose: To study the influence of non-invasive ventilator and tiotropium bromide on pulmonary function sleep quality patients with chronic obstructive disease (COPD) combined apnea-hypopnea syndrome (OSAHS).Methods: One hundred twenty COPD-OSAHS were selected randomly assigned to control group (CG) treatment (TG), 60 subjects in each group. Non-invasive therapy was used both groups, based conv...

BACKGROUND The role of inflammation in all stages of atherosclerotic disease is increasingly recognized especially in last few years. The chronic inflammatory process can develop to an acute clinical event by the induction of plaque rupture and therefore cause acute coronary syndrome. Creactive protein is a strong predictor of clinical outcome in coronary artery disease and inflammation has bee...

p53 is a key tumor suppressor gene that is targeted for inactivation during human tumorigenesis. In this study, we produced and characterized polyclonal antihuman p53 antibody. The cDNA encoding the completehuman p53 protein was cloned into pGEX-4T-1 and expressed in Escherichia coli as a fusion protein with Schistosoma japonicum glutathione S-transferase (GST). The rabbits were immunized...

OBJECTIVE To investigate the effects of nonsurgical periodontal therapy on levels of high-sensitivity C-reactive protein in the sera and its association with body mass index and high density lipoprotein in subjects with severe periodontitis. METHODS Sera from 28 subjects (mean age: 34.36±6.24; 32% men) with severe periodontitis and 27 healthy controls (mean age: 33.18±6.42; 33% men) were coll...