Animal models play a critical role in diabetes research, aiding the comprehension of both type 1 and 2 pathogenesis assessment potential therapeutic interventions. These offer numerous advantages, including ability to induce stable hyperglycemia hyperlipidemia, minimal variability, opportunity study genetic mutations single gene effects. However, they also present limitations such as lengthy in...

Acrylamide (AA) is an important industrial chemical agent that is mainly used in the production of polymers and copolymers. Recently it has been attention because of its production in the diet at high-temperature (>120 ºC) processes such as cooking, frying, toasting, roasting or baking of high carbohydrate foods. According to high exposure to acrylamide, recognition of its toxic effect is ...

background: this study conducted as part of a screening program for the promotion of community health in the primary care setting of ormos korthi in andros, greece. the objective of this study was to identify the levels of glucose and total cholesterol in individuals without major cardiovascular problems in order to identify cases of undetected dyslipidemia and high blood glucose levels, in a r...

Aflatoxins (AFs) are a group of highly toxic mycotoxins mainly produced by Aspergillus flavus and parasiticus, which considered natural contaminants food feed to the liver, carcinogens mutagenic. Therefore, reducing their toxicity in body organism is great importance. In this study, aqueous extract leaves was evaluated (green Tea sage) reduce caused aflatoxins. Two concentrations aflatoxins (0....

BACKGROUND A recent survey puts the global dialysis population at 535100; of those on peritoneal dialysis, 85% are on continuous ambulatory peritoneal dialysis. Current hyperosmolar dialysis fluids are toxic to peritoneal cells and inhibit certain host-defence functions. An alternative preparation, glucose polymer, has recently been developed. METHODS Mesothelial cell viability, interleukin-6...

High glucose concentrations can decrease degradation of mesangium by reducing the activities of matrix metalloproteinases (MMPs). The aim of this study was to investigate the effects of glycation of mesangium matrix on MMP-2, the principal MMP secreted by mesangial cells to degrade type IV collagen. Also examined were membrane type 1 MMP (MT1-MMP), tissue inhibitors of MMPs (TIMP)-1 and -2, and...

dichloroacetate (dca) as a small, cheap and available anticancer agent, is a pyruvate mimetic compound that stimulates the activity of pyruvate dehydrogenase (pdh) enzyme through inhibition of pyruvate dehydrogenase kinases (pdhk1-4). dca turns on programed cell death (apoptosis) which suppressed in tumor cells and therefore inhibits tumor growth. dca also interferes with the glucose uses of ca...