The hyper-systemizing theory of autism proposes that the systemizing mechanism is set too high in people with autism. As a result, they can only cope with highly lawful systems, and cannot cope with systems of high variance or change (such as the social world of other minds). They appear 'change-resistant'. This proposal extends the extreme male brain theory of autism. Finally, evidence is revi...

Failure to develop normal language comprehension is an early warning sign of autism, but the neural mechanisms underlying this signature deficit are unknown. This is because of an almost complete absence of functional studies of the autistic brain during early development. Using functional magnetic resonance imaging, we previously observed a trend for abnormally lateralized temporal responses t...

Abstract Mobile apps represent a resource with great potential for encouraging the development of many skills, given high number available and quick access to them. Many professionals families include these resources in education therapy children autism. For group such particular needs, review is importance, since, due their characteristics, must provide content, design pedagogical aspects that...

Augmentative and Alternative Communication (AAC) is an expressive receptive method of communication that helps in developing language skills for people with speech and/or impairment. Autism spectrum disorders (ASD) children who lack can improve functional by personalizing AAC intervention. This paper based on literature to promote interventions enhance English acquisition autism disorder childr...

BACKGROUND Dysfunctions in the PI3K/mTOR pathway have gained a lot of attention in autism research. This was initially based on the discovery of several monogenic autism spectrum disorders with mutations or defects in PI3K/mTOR signaling components. Recent genetic studies corroborate that defective PI3K/mTOR signaling might be a shared pathomechanism in autism disorders of so far unknown etiolo...

A suite of recent studies has reported positive genetic correlations between autism risk and measures of mental ability. These findings indicate that alleles for autism overlap broadly with alleles for high intelligence, which appears paradoxical given that autism is characterized, overall, by below-average IQ. This paradox can be resolved under the hypothesis that autism etiology commonly invo...

background: this is a case series of 76 knees of 62 patients who underwent upper tibial valgus osteotomy for treatment of medial compartment osteoarthritis during a 20-year period and who were followed for a mean of 7.6 years.   methods: the patients were evaluated by validated outcome assessment systems of general health status short form (sf-36), the western ontario mcmaster osteoarthritis in...