Mitogen-induced gamma interferon production by human lymphoid cell cultures was studied in the presence of calcium entry blockers. A dose-dependent inhibition was found in the presence of drug concentrations down to 10(-5) M. This finding shows that calcium flow through lymphocyte membranes after oxidation of membrane-bound galactose residues is also critical for triggering interferon production.

The goal of the 1-year observational, multicentre, open-label study reported here was to identify factors influencing adherence to high-dose interferon alfa-2b adjuvant therapy in patients at high risk of recurrence following surgical excision of malignant melanoma. The study was carried out in 23 tertiary-care centres across Canada.The 225 patients enrolled in the study all had malignant melan...

α-Interferon is an antiviral agent used in treatment of chronic hepatitis B. Triggering of the underlying autoimmune disease or exacerbation of pre-existing auto immune disease is documented with α-interferon, but there are few reports about occurrence of autoimmune disorders such as systemic lupus erythematosus, Vitiligo, hypo and hyperthyroidism after administration of α-interferon in the lit...

Preeclampsia is a "disease of theory" because the cause and pathophysiology preeclampsia still uncertain. In invasion trophoblast cells does not occur completely, spiral arteries undergo remodeling so it has component muscle elastic tissue, in addition to endothelial dysfunction characterized by reduced relaxation factor increased contraction resulting ischemia placenta The end result hypoxia, ...

Acyclovir had a dose-dependent, mild, but significant, inhibitory effect on interferon-stimulated human antiviral natural killer cytotoxicity in vitro. In a murine model of neonatal herpes simplex virus infection, acyclovir significantly (P < 0.05) increased survival afforded by the injection of human interferon and human mononuclear leukocytes from 67.8 to 88.6%.

patients receiving high dose induction followed by combination interferon and ribavirin therapy Hugo R. Rosen*, Ruy R. Ribeiro, Leor Weinberger, Stephanie Wolf, Minjun Chung, David R. Gretch, Alan S. Perelson Division of Gastroenterology and Hepatology, Portland Veterans Affairs Medical Center, Portland, OR, USA Division of Molecular Microbiology and Immunology, Oregon Health & Science Universi...