Since disturbance of angiogenesis predisposes to ischemic injuries, attempts to promote angiogenesis have been made to improve clinical outcomes of patients with many ischemic disorders. While hypoxia inducible factors (HIFs) stimulate vascular remodeling and angiogenesis, hyperlipidemia impairs angiogenesis in response to various pro-angiogenic factors. However, it remains uncertain how HIFs r...

Hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha display unique and sometimes opposing activities in regulating cellular energy homeostasis, cell fate decisions, and oncogenesis. Macrophages exposed to hypoxia accumulate both HIF-1alpha and HIF-2alpha, and overexpression of HIF-2alpha in tumor-associated macrophages (TAMs) is specifically correlated with high-grade human tumors and p...

Abstract Objectives Gliomas are highly aggressive neuroepithelial-layer malignancies. Hypoxia-inducible factor 1α (HIF-1α) was revealed to be upregulated in gliomas under hypoxia. Nevertheless, its role glioma cells remains elusive. We attempted clarify the molecular mechanism of HIF-1 underlying glioma. Methods Cellular models were established mimic characteristics RT‒qPCR used detect HIF-1α a...

Terrein is a fungal metabolite that has already been reported with anticancer properties. However, the effect on aggressive phenotype of cancer cells not elucidated yet. In present study, cytotoxicity terrein was first determined against lung (A549) model and compared several normal cell lines (Vero, L6, H9C2 cells). The data demonstrated had specific A549 relative to high selectivity index val...

PURPOSE Renal cell carcinoma (RCC) is the most common malignancy of the kidney composed of specific tumor types. The sporadic conventional RCCs are, in contrast to the other RCC types, characterized by a high rate of von Hippel-Lindau (VHL) mutations and hypermethylation. The majority of these tumors lack functional VHL protein (pVHL) that leads to increased hypoxia-inducible factor 1alpha (HIF...

In the ischemic or hypoxic brain, astrocytes appear to be one of the main sources of erythropoietin (EPO). In this study, we investigated the differential contribution of hypoxia inducible factor (HIF) isoforms to the regulation of hypoxic EPO expression in cultured astrocytes. In addition, using an in vitro model of oxygen-glucose deprivation (OGD), we studied the role of HIF-1alpha and HIF-2a...

Hypoxia-inducible factor-1alpha (HIF-1alpha) is a transcription factor that regulates the oxygen-dependent expression of a number of genes. This transcription factor may contribute to the abundant expression of many genes in renal medullary cells that function normally under hypoxic conditions. The present study was designed to determine the characteristics of HIF-1alpha cDNA cloned from the ra...

ability in oxygen delivery and diffusion of the blood vessels and increased oxygen consumption in the rapidly proliferating cancer cells both contribute to reduced oxygen availability in the solid tumors, a major signature of the tumor microenvironment [1]. The oxygen concentration is dynamically changed within the tumor, and thus tumor cells are frequently subjected to acute or chronic hypoxia...

Hypoxia or reduced oxygen level is frequently observed in solid tumors. Hypoxia plays a significant role in solid tumor progression and metastasis by stabilizing hypoxia inducible factor (HIF) to activate gene transcription. The majority of human genes are alternatively spliced, producing RNA isoforms that code for functionally distinct proteins. Thus, it is unclear if HIF promotes tumor progre...