This report is the first of a series on a method for treatment of hypertension by oral hexamethonium chloride and hydrazinophthalazine. When strictly followed blood pressure was maintained at reasonable or normal levels in 80 per cent of 258 cases of severe hypertension. The malignant stage, when present, was reversed. Renal insufficiency and severe cerebral atherosclerosis limit the effectiven...

Under controlled conditions the effects of various "sympatholytic" agents on the cardiovascular responses to epinephrine and norepinephrine were compared in man. The dosages of the sympatholytic drugs administered approximated those usually employed clinically. Such basic data are given for the following agents: Dibenamine, the imidazoline derivatives [Priscoline and Regitine (C-7337)], the dih...

Under controlled conditions the effects of various “sympatholytic” agents on the cardiovascular responses to epinephrine and norepinephrine were compared in man. The dosages of the sympatholytic drugs administered approximated those usually employed clinically. Such basic data are given for the following agents: Dibenamine, the imidazoline derivatives [Priscoline and Regitine (C-73i)], the dihy...

Under controlled conditions the effects of various "sympatholytic" agents on the cardiovascular responses to epinephrine and norepinephrine were compared in man. The dosages of the sympatholytic drugs administered approximated those usually employed clinically. Such basic data are given for the following agents: Dibenamine, the imidazoline derivatives [Priscoline and Regitine (C-7337)], the dih...

The element of control in modern anaesthesia is of special value in ophthalmology, where smooth operating conditions and a trouble-free respiratory period are obligatory. While this feature is of value in controlling bleeding, eye movements, and squeezing, the ability to control intra-ocular tension is of special significance. During operation chlorpromazine, promethazine and pethidine have bee...

Further data are presented concerning the unusual hemodynamic effects of 1 -hiydraziniophthalazine. Previous observations demonstrating a marked increase in cardiac output in noimotensive subjects are confirmed in hypertensive patients. The splanchnic vascular bed is one of the sites of increased blood flow. The similarity between the hemodynamic effects of 1-bydr.azinophthalazine and pyirogens...

Hourly measurements of the transient mydriasis and intraocular pressure decrease after right cervical ganglionectomy and left cervical sympathotomy were simultaneously performed in conscious rabbits. The times of onset of these phenomena after the denervation were 14.51 0.21 hr. (n = 8) and 18.71 ± 0.78 hr. (n = 7), respectively. Their duration values were 18.01 ± 0.89 hr. (n = 8) and 18.81 ± 1...

Although venous capacitance has been studied in the neurally isolated tissue or in the in vitro vein segment, this is the first study of sympathetic regulation of the pressure-diameter relation in mesenteric veins in situ, where innervation is kept intact. In 25 alpha-chloralose-anesthetized rabbits, mesenteric vein diameter (679 +/- 27 microns, ranges of 380-1,050 microns at initial state) and...