background: herpes simplex virus (hsv) is a member of herpesviridae and a leading cause of human viral diseases. meningitis occurs as a complication of hsv-1 or hsv-2 primary infection. objectives: we aimed to evaluate hsv meningitis in children in gorgan province, iran. patients and methods: forty-five cerebrospinal fluid samples were taken from children referred with meningitis symptoms. samp...

background patients with beta thalassemia suffer from increased susceptibility to infections and putridity plays a major role in the patient's morbidity and mortality. the risk of transfusion-transmitted viral infection is well known in these patients. however, there is dearth of information about the seroprevalence of herpes simplex virus (hsv) infection in patients with beta thalassemia in li...

mice under the control of a cryptic promoter. kinase is expressed in the testes of transgenic The herpes simplex virus type 1 thymidine

The presence, frequency, and relationship of ocular and oral shedding of herpes simplex virus to previous herpes keratitis was investigated. This was to determine if a history of herpes keratitis predisposes to shedding of the herpes simplex virus into the tear film and/or mouth. Swabs were collected from the eyes and mouth of two groups of patients thrice weekly over a two- to four-month perio...

Human immunodeficiency virus type 1 (HIV-1) infection continues to spread in developing countries, mostly through heterosexual transmission. The development of a safe and cost-effective topical microbicide, effective against a range of STDs including HIV-1, would greatly impact the ongoing epidemic. When formulated in a vehicle, a micronized form of cellulose acetate phthalate (CAP), which is a...

About 1 in 5 sexually active adults in the United States has serologic evidence of genital herpes caused by herpes simplex virus type-2. Neonatal herpes simplex virus infection is a serious consequence of genital herpes infection. Herpes infection in neonates causes significant morbidity and neurologic damage and generally has a case-fatality ratio untreated of 60%. It is estimated that 440 to ...

abstract background and aims: herpes simplex virus (hsv) is a common cause of corneal disease and is the leading infectious cause of corneal blindness among developed nations. this study is aimed to provide an estimation of the incidence of herpes simplex virustype-1, 2(hsv1, 2) and varicella zoster virus (vzv) in tears and swab from eye infection by polymerase chain reaction (pcr) in eye disea...

  Herpes simplex virus type 1 establishes a latent infection in the peripheral nervous system following primary infection. During latent infection, virus genome exhibit limited transcription, with the HSV LATs consistently detected in latency infected ganaglia. Following ocular infection viral latency develops in the trigeminal ganglia. In this study PCR has been used for detection of HSV-1 nuc...

acyclovir (9-[2-hydroxyethoxymethyl] guanine) is an acyclic nucleoside analogue of guanosine which is a potent and selective antiviral agent. acycloviris converted to the monophosphate by thymidine kinase the virus-specific form of this enzyme and is subsequently converted to the triphosphate by the host cell kinase. acyclovir triphosphate inhibits viral dna-polymerase terminating the chain and...