We developed a murine model of ocular herpes simplex virus (HSV) disease which is particularly suited for testing stromal keratitis because most animals show some evidence of infection. Using this model, we characterized the ocular disease patterns caused by ten recent low-passage clinical isolates of HSV-1, as well as those caused by the established laboratory strains HSV-1 KOS and HSV-2 333. ...

Abstract Purpose Herpes simplex diffuse endotheliitis with accompanying feathery infiltration is difficult to diagnose due corneal findings that are similar fungal keratitis. This case series reports on the effectiveness of using real-time polymerase chain reaction (PCR) herpes in appearance Methods After extracting smear sample DNA, samples were then applied two independent PCR assays, a quali...

BACKGROUND An uncommon case of stromal keratitis and anterior uveitis due to herpes simplex virus type 2 (HSV-2) is reported. CASE The patient was a 3-year-old boy admitted for conjunctival injection of the right eye of unknown cause, accompanied by corneal opacity and anterior uveitis. OBSERVATIONS High titers of antibodies against HSV and Epstein-Barr virus (EBV) were found in blood sampl...