BACKGROUND Lumbar discectomy and laminectomy in patients with intervertebral disc herniation (IDH) is common, with variable reported reoperation rates. Our study examined which baseline characteristics might be risk factors for reoperation and compared outcomes between patients who underwent reoperation and those who did not. METHODS We performed a retrospective subgroup analysis of patients ...

Asiatic acid and corosolic acid are two natural products identified as biofilm inhibitors in a biofilm inhibition assay. We evaluated the activities of these two compounds on Pseudomonas aeruginosa biofilms grown in rotating disk reactors (RDRs) in combination with tobramycin and ciprofloxacin. To determine the ruggedness of our systems, the antibiotic susceptibilities of these biofilms were as...

Hypertrophy of the ligamentum flavum has been reported to occur in the prolapsed intervertebral disc syndrome. The ligaments from 28 patients were compared with a necropsy control group (18). Only minor histological anomalies were noted in two patients and the ligament was not thickened in cases of disc prolapse. In addition, there was no evidence to suggest previous trauma to the ligaments ass...

SUMMARY OF BACKGROUND DATA The Spine Patient Outcomes Research Trial (SPORT) was designed to assess the relative efficacy and cost-effectiveness of surgical and nonsurgical approaches to the treatment of common conditions associated with low back and leg pain. OBJECTIVES To describe the rationale and design of the SPORT project and to discuss its strengths and limitations. STUDY DESIGN Desc...

high-throughput screening (HTS) has revolutionized the process of drug discovery. Automation and miniaturization have allowed biotech companies to screen hundreds of thousands of compounds against disease targets, in the hope of identifying the precious few that can be developed into commercial, patentable medicines. To use a fashionable analogy, it’s like speed dating for medicines. But this a...

STUDY DESIGN Prospective randomized and observational cohorts. OBJECTIVE To compare outcomes of patients with and without workers' compensation who had surgical and nonoperative treatment for a lumbar intervertebral disc herniation (IDH). SUMMARY OF BACKGROUND DATA Few studies have examined the association between worker's compensation and outcomes of surgical and nonoperative treatment. ...

Editor’s key points † Several factors that influence intracranial pressure (ICP) also influence intraocular pressure (IOP). † Injections into the epidural space can cause cerebrospinal fluid shifts into the cranial space. † This has the potential to increase ICP and IOP. † The authors studied the effect of cervical epidural injections (14 ml) on IOP. Background. Cervical epidural injection (CEI...

The aim of this study was to evaluate the prognostic value of concurrent measurement of serum phosphorylated neurofilament heavy subunit (pNF-H) concentration and intramedullary T2W hyperintensity in paraplegic to paraplegic dogs. Our hypothesis was that concurrent measurement of these would provide a more accurate prediction of functional outcome in dogs with thoracolumbar intervertebral disc ...

Results of a 1999 November 16–17 BeppoSAX observation of the low-mass X-ray binary X 2127+119 located in the globular cluster M15 are presented. The system is believed to be one where the central neutron star is normally obscured by the accretion disk, and only X-rays scattered into our line of sight by an extended accretion disk corona (ADC) are observed. The 0.1–10 keV lightcurve is energy de...