نتایج جستجو برای: herfindal concentration
تعداد نتایج: 381037 فیلتر نتایج به سال:
A series of 2-N-alkyl-3-aryl-3-alkoxyisoindolinones has been synthesised and evaluated as inhibitors of the MDM2-p53 interaction. The most potent compound, 3-(4-chlorophenyl)-3-(4-hydroxy-3,5-dimethoxybenzyloxy)-2-propyl-2,3-dihydroisoindol-1-one (NU8231), exhibited an IC50 of 5.3 +/- 0.9 microM in an ELISA assay, and induced p53-dependent gene transcription in a dose-dependent manner, in the S...
As the field of psychology continues to expand and evolve, one fruitful avenue of exploration has been the integration of mindfulness into psychological theory and practice. Mindfulness is defined as the awareness that arises out of intentionally attending in an open and discerning way to whatever is arising in the present moment. Two decades of empirical research have generated considerable ev...
It is generally acknowledged that the urban environment presents different types of risk factors, but how the structural effects of areas influence the risk levels in neighboring areas has been less widely investigated. This research assesses the local effects of burglary contributory factors on burglary over small areas in a large metropolitan region. A comparative framework is developed for a...
Based on a known pharmacophore model for 5-HT₆ receptor antagonists, a series of novel extended derivatives of the N-arylsulfonyindole scaffold were designed and identified as a new class of 5-HT₆ receptor modulators. Eight of the compounds exhibited moderate to high binding affinities and displayed antagonist profile in 5-HT₆ receptor functional assays. Compounds 2-(4-(2-methoxyphenyl)piperazi...
From the mid-1980s to the mid-1990s, several prominent feminist legal scholars made a case for “difference feminism.” Inspired by psychologist Carol Gilligan’s classic text, In a Different Voice, these scholars argued that social relationships, caring, and the emotions should be recognized as important to jurisprudence and legal regulation. Today, difference feminism is no longer a dominant mov...
After mindfulness is defined, a brief history of the research on the topic to date is reviewed. This work essentially falls into three categories: health, business, and education. Considerations of mindlessness as a social issue are then addressed. A brief introduction to the articles in this issue follows. These articles speak to mindfulness as it relates to potential solutions to social probl...
Drinking of 3 liters of so called low alcohol beer (0.5 vol.% as well as 0.9 vol.%) within 2 hours leads only to very low or no blood alcohol values during a drinking experiment (19 persons). These results are expected considering the kinetics of resorption and elimination of alcohol in human body. Consumption of low alcohol beers instead of traditional beer should have a positive effect on tra...
Purpose The Stress Management and Resiliency Training (SMART) program has shown efficacy for reducing anxiety and perceived stress and increasing resilience and quality of life. SMART has traditionally consisted of an in-person training session with an instructor and follow up teleconferences over 12-24 weeks. The purpose of this study was to assess whether self-directed SMART training using on...
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