Three patients with the sicca syndrome and chronic sensory neuropathy are described; in two of them neuropathy was the presenting feature of the disease. The sicca syndrome can give rise to a characteristic neurological syndrome comprising areflexia and asymmetrical sensory loss, particularly of proprioception, in the limbs. This is often associated with tonic pupils and trigeminal anaesthesia.

A large kinship is reported with dominantly inherited spastic paraplegia starting in the first decade of life; its clinical evolution was indistinguishable from that of "pure" hereditary spastic paraplegia (HSP). However, all patients studied had electrophysiological evidence of a predominantly sensory polyneuropathy, which was confirmed on nerve biopsy in three. The histological findings indic...

Seventy five patients with chronic idiopathic axonal polyneuropathy (CIAP) were studied for five years. The standardised and quantified neurological examination shows that progression of CIAP is slow, and handicap, if present, is not severe. During the follow up period a definite cause of the neuropathy was found in only four patients (two hereditary motor and sensory neuropathy type 2, one sen...

Paraneoplastic polyneuropathies are among the most common distal neurological complications of systemic cancer on the nervous system. All peripheral neuropathy types, such as demyelinating, axonal, motor, sensory, or autonomic, can present in association with cancer and can have a paraneoplastic etiology (1). Classical paraneoplastic peripheral neuropathy is typically a sensory neuropathy with ...

BACKGROUND Hereditary sensory and autonomic neuropathy (HSAN) type II with WNK1/HSN2 gene mutation is a rare disease characterized by early-onset demyelination sensory loss and skin ulceration. To the best of our knowledge, no cases of an autonomic disorder have been reported clearly in a patient with WNK/HSN2 gene mutation and only one case of a Japanese patient with the WNK/HSN2 gene mutation...

Introduction Small-fibre length-dependent sensory-motor and autonomic neuropathy is the hallmark of TTR-FAP. SUDOSCAN was recently introduced as a quick and non-invasive method that measures electrochemical skin conductance (ESC) of palmar and plantar surfaces, through reverse iontophoresis. It has been described as a promising diagnostic tool in distal symmetric polyneuropathies, such as diabe...

Recent evidence is reviewed to examine relations among sensory, sensorimotor, and cognitive aging. Age-heterogeneous cross-sectional data sets show substantial covariation among sensory, sensorimotor and intellectual abilities, and an increase in covariation from adulthood to old and very old age. Recent longitudinal analyses suggest that changes in sensory and intellectual functioning are inte...

Leprosy has been labelled as a great imitator since times immemorial. This mainly is because of the wide range of its clinical presentations. In endemic regions it is important to entertain the possibility of leprosy even in atypical presentations so as to avoid misdiagnosis. Here we report three cases of leprosy with uncommon disease presentations. First case had presented with eczematous morp...

PURPOSE OF THE STUDY Combined vision and hearing loss [dual sensory loss (DSL)] is commonly experienced by older adults. The literature on comorbidities and outcomes associated with DSL in older adults is limited and thus a systematic review was conducted to explore the existing research and identify gaps in the evidence base. DESIGN AND METHODS A review was conducted in accordance with the P...

Although the oldest old are the fastest growing segment of the population, little is known about their cognitive performance. Our aim was to compile a relatively brief test battery that could be completed by a majority of individuals aged 90 or over, compensates for sensory losses, and incorporates previously validated, standardized, and accessible instruments. Means, standard deviations, and p...