Hepatocytes are highly susceptible to cytokine stimulation and are fundamental to liver function. We established primary canine hepatocyte cultures to study effects of anti-inflammatory agents with hepatoprotective properties. Hepatocyte cultures were incubated with control media alone, silybin (SB), or the more bioavailable silybin-phosphatidylcholine complex (SPC), followed by activation with...

An aqueous extracts of stem and leaves of Boerhaavia Diffusa (Aq.EBD) and leaves of Anisochilus Carnosus (Aq.EAC) was studied for hepatoprotective, analgesic and antipyretic activity. Hepatotoxicity was introduced in Albino rats of either sex by intraperitoneal injection of CCl4 (in olive oil). Tail immersion method and Hot plate method in mice were studied for analgesic activity, Yeast induced...

Administration of hydroalcoholic extract of Cissampelos pareira roots (CPRE) and standard drug silymarin in rats showed significant hepatoprotective action against CCl4 induced hepatotoxicity. Elevated serum marker enzymes of AST, ALT, ALP and serum bilirubin were significantly reduced to near normal level in CPRE treated rats. Lipid peroxidation level was decreased significantly in CPRE 100, 2...

Objective: To evaluate the hepatoprotective potential of methanol extract of roots and rhizomes of Smilax zeylanica L on carbontetrachloride (CCl4) induced hepatotoxicity in Wistar albino rats. Methods: Hepatotoxicity was induced in Wistar albino rats of either sex by administration of CCl4 0.5 ml/kg p.o. once a day for 7 days. The methanol extract of roots and rhizomes of Smilax zeylanica L we...

AIM: This study was conducted to study the hepatoprotective property of Hemidesmus indicus (L.) R.Br. roots. METHODS: Hepatoprotective properties of the methanol extract of the roots of H. indicus var. pubescens were evaluated on paracetamol induced hepatotoxicity. Hepatotoxicity was induced in albino Wistar rats by the administration of paracetamol (1g/kg), p.o. for 7 days. Methanol extract of...

Raphanus sativus (Cruciferaceae), commonly known as radish is widely available throughout the world. From antiquity it has been used in folk medicine as a natural drug against many toxicants. The present study was designed to evaluate the hepatoprotective activity of radish (Raphanus sativus) enzyme extract (REE) in vitro and in vivo test. The IC50 values of REE in human liver derived HepG2 cel...

Phyllanthus niruri L. (Euphorbiaceae) is a well-known hepatoprotective herbal plant. The aim of this study was to investigate the hepatoprotective action of the protein isolate of Phyl-lanthus niruri (P. niruri) against acetaminophen (APAP) induced hepatotoxicity. Protein iso-late of P. niruri was intraperitoneally injected in mice either prior to (preventive) or after the induction of toxicity...

BACKGROUND The genus Amaranthus has potential activity as a hepatoprotective agent. OBJECTIVE The present pharmacological investigation focuses on evaluation of the efficacy of aqueous extract of roots of Amaranthus tricolor Linn. for their protection against paracetamol (PCM) overdose induced hepatotoxicity. MATERIALS AND METHODS The aqueous extract of roots of A. tricolor Linn. was prepar...

OBJECTIVE This study evaluates hepatoprotective potential of Feronia limonia stem bark (FSB) extracts and fractions using experimental models. MATERIALS AND METHODS Activity levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) and cell viability were evaluated in HepG2 cells treated with carbon tetrachloride (CCl4) in presence or absence of FL extracts or fractions. A...

Plumbago zeylanica root has been used traditionally to treat various body ailments including liver diseases. The present study was designed to investigate the hepatoprotective effects of standardized methanolic extract of Plumbago zeylanica root on paracetamol, CCl4 and alcohol induced hepatic injuries in rats and its possible mechanism(s) of hepatoprotection. Administration of hepatotoxicants ...