Hepatocellular carcinoma (HCC) is a primary tumor of the liver that develops in setting chronic disease. HCC difficult to diagnosis due it requiring use multiple imaging modalities with goal detect tumors when they are less than or equal 2 cm size allow all possible treatment options be used. Herein, we discuss 69-year-old male stage IV cancer residing hospice presenting left middle finger oste...

BACKGROUND Although accumulating data has implicated a role for the Apelinergic system in cirrhosis, the role of Apelin during different stages of fibrogenesis has not been clarified, whereas no studies have been conducted on its expression in human hepatocellular carcinoma (HCC). This study aimed to elucidate its role in hepatic remodelling and carcinogenesis. METHODS Immunolocalization of A...

We report herein a rare instance in which a patient presented with a hemorrhagic cerebral metastasis as the initial manifestation of a hepatocellular carcinoma (HCC). A few cases of cerebral metastasis from HCC have been reported in the literature, mainly from eastern countries. This is the first report from South America of a cerebral metastasis from hepatocellular carcinoma.

BACKGROUND Human fibroblast growth factor 19 (FGF19), its receptor (FGFR4) and EpCAM play an important role in cell proliferation, differentiation, motility, and overexpression have been linked to hepatocellular carcinoma (HCC). The aim of this study was to evaluate the FGF19 signals responsible for the progression of HCC arising from fatty liver. RESULTS FGF19 level was significantly increas...

Abstract Background Hepatitis B virus (HBV) infection is a high-risk factor of hepatocellular carcinoma (HCC). Cellular immune responses are essential for HCC development, and the CD4+ CD8+ T subtypes identified as primary anti-tumor cells. In study, we investigated effect mechanism amygdalin in cellular response HBV-related progression. Methods The cell proliferation was examined by MTT analys...

Abstract Immune-checkpoint blockade (ICB) therapies have transformed the treatment landscapes of hepatocellular carcinoma (HCC). However, immunosuppressive tumor microenvironment (TME) constructed by cells restricts responsiveness ICB to a minority patients. Triggering receptor expressed on myeloid cells-2 (TREM2) counteracts inflammation and maintains metabolic fitness in cells. Single-cell RN...

Hepatocellular carcinoma (HCC) is a major cause of cancer-related death worldwide. Understanding the pathogenesis HCC has significantly improved in past few years due to advances genetics, molecular biology and pathology. Several subtypes have been identified with different backgrounds outcomes, leading possible changes disease management challenging role imaging. Indeed, despite its pivotal di...

Hepatocellular carcinoma (HCC) is associated with poor prognosis and fluctuations in immune status. Although studies have found that secreted phosphoprotein 1 (SPP1) involved HCC progression, its independent prognostic value immune-mediated role remain unclear. Using The Cancer Genome Atlas Gene Expression Omnibus data, we low expression of SPP1 significantly improved survival patients correlat...

Although arsenic trioxide (As2O3) has been successfully employed in treatment of patients with APL (acute promyelocytic leukemia), the sensitivity of solid tumor cells to this treatment was much lower than APL cells. The single agent of As2O3 was inefficient for treatment of hepatocellular carcinoma (HCC) in phase II trial demonstrating that new m...

CONTEXT Alpha-1-antitrypsin (A1AT) is the most abundant liver-derived, highly polymorphic, glycoprotein in plasma. Hereditary deficiency of alpha-1-antitrypsin in plasma (A1ATD) is a consequence of accumulation of polymers of A1AT mutants in endoplasmic reticulum of hepatocytes and other A1AT-producing cells. One of the clinical manifestations of A1ATD is liver disease in childhood and cirrhosi...