Pharmacology: Rosuvastatin selectively and competitively inhibits HMG-CoA reductase, the rate-limiting enzyme in the production of mevalonate, a cholesterol precursor. Rosuvastatin has high activity in, uptake into, and selectivity for the liver, the target organ. It enhances uptake and catabolism of LDL by increasing hepatic LDL receptor levels. It also inhibits the hepatic VLDL synthesis, red...

The effect of acute and chronic ethanol intake on hepatic glycerolipid biosynthesis in the hamster was studied by in vivo and in vitro techniques. The results were compared with those from control hamsters receiving isocaloric amounts of glucose. Both chronic and acute ethanol intake elevated serum and hepatic triglyceride concentrations and induced a rapid rise in the capacity of neutral glyce...

Spontaneous hepatic rupture, which is a complication of hypertension in pregnancy, is extremely rare. However, high maternal and perinatal mortality rates are observed. Moreover, it is frequently associated with severe preeclampsia or HELLP syndrome (a group of symptoms that include hemolytic anemia, hepatic enzyme increase, and thrombocytopenia). About 80% of the cases involve women who are in...

Curcumin (CUR) is a highly pleiotropic molecule and possesses anti-inflammatory, hypoglycemic, antioxidative, wound-healing and antimicrobial activities. The present study was carried out to investigate whether CUR plays any beneficial role in streptozotocin (STZ) induced hepatic pathophysiology in diabetic rats. STZ exposure increased hepatic damage associated serum markers (ALT, ALP and LDH) ...

acute cholangitis (ac) is commonly observed in general practice with different causes. we report a case of recurrent ac caused by anomaly of the right hepatic artery, as a rare underlying condition.

Introduction: Aflatoxins, known as causative factors of hepatic and extra-hepatic carcinogenesis within humans, are extremely teratogenic, mutagenic, toxic, and carcinogenic compounds. Materials & Methods: This study was undertaken to determine the occurrence of aflatoxin M1 (AFM1) in 40 raw milk and 47 pasteurized milk samples collected during spring and winter. In order to analyze the samp...

The objective of this experiment was to determine the effect of long-term low-dose administration of lead (Pb) on thyroid function in sheep. In this experiment 10 healthy Iranian male sheep, aged about oneyear- old were randomly allocated into two equal groups of control (n = 5) and experiment (n = 5). Both groups were kept under the same conditions of food and environment. The treatment group ...

Tryptophan 2,3-dioxygenase (TDO), a liver-specific cytosolic hemoprotein, is the rate-limiting enzyme in L-tryptophan catabolism and thus a key serotonergic determinant. Glucocorticoids transcriptionally activate the TDO gene with marked enzyme induction. TDO is also regulated by heme, its prosthetic moiety, as its expression and function are significantly reduced after acute hepatic heme deple...

Ischemia?reperfusion injury (IRI), also called reoxygenation injury, is the outcome of inflammatory processes and oxidative damage through induction stress. In clinical setting, IRI contributes to severe hepatic including liver cell death by apoptosis ferroptosis. Ferroptosis a novel type in that involves small molecules inhibit glutathione biosynthesis or peroxidase 4 (GPX4), which glutathione...

BACKGROUND The purpose of the present study is to investigate the association of nonalcoholic fatty liver disease (NAFLD) with the doppler waveform pattern of hepatic veins and portal vein doppler indices. OBJECTIVES This assay may be useful in evaluating the natural course of NAFLD and monitor treatment efficacy on follow-up. PATIENTS AND METHODS This case control study was performed in 31...