نتایج جستجو برای: heparan sulfate proteoglycans
تعداد نتایج: 62045 فیلتر نتایج به سال:
Background: HIV-1 p17 binds heparin and heparan sulfate proteoglycans of the cell surface. Results: heparin/p17 interaction occurs through heparin sulfate groups and a linear basic motif of p17 N-terminus, also involved in p17/CXCR1 interaction. Conclusion: targeting the basic motif inhibits p17/receptors interaction and consequent biological activities. Significance: heparin-like molecules rep...
Chronic inhalation of cadmium at the workplace or in cigarette smoke is associated with emphysema, a disease characterized by extensive disruption of lung connective tissue. We have previously shown that cadmium, at noncytotoxic doses, inhibits fibroblast procollagen production in vitro, with maximal inhibitory effects of 69 +/- 6% (P < 0.01) at 30 µM cadmium chloride (CdCl2). In this pape...
Contact of various cells with extracellular matrix molecules modulates their cellular functions and phenotype. Most investigations have employed dishes coated with purified matrix constituents or plain collagen I lattices omitting the effects of other important matrix components such as proteoglycans. In this study we analyze the effect of purified glycosaminoglycans (GAGs) on human fibroblasts...
Fibroblast growth factors (FGFs) are among the best-studied heparin-binding proteins, and heparan sulfate proteoglycans regulate FGF signalling by direct molecular association with FGF and its tyrosine kinase receptor, FGFR. Two recently determined crystal structures of FGF-FGFR-heparin complexes have provided new structural information on how heparin binds to FGF and FGFR, and lead to differen...
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