Recent achievements in the understanding of molecular events involved in the pathogenesis of central nervous system (CNS) injury have made gene transfer a promising approach for various neurological disorders, including cerebrovascular diseases. However, special obstacles, including the post-mitotic nature of neurons and the blood-brain barrier (BBB), constitute key challenges for gene delivery...

Factor X deficiency is a severe rare hemorrhagic condition inherited as an autosomal recessive trait. It is one of the most severe recessive inherited coagulation disorders. We analyzed the clinical manifestations, laboratory phenotype and genotype in 10 patients with severe Factor X deficiency and in their heterozygous relatives. The most frequent bleeding episodes were hematomas (70%) and gum...

The etiology of cerebral hemiatrophy may be congenital or acquired. Trauma, infection, vascular abnormality, ischemic and hemorrhagic conditions may be the etiologic factors in acquired type. There is limited information about its association with other disorders in the literature. We presented three new cases of cerebral hemiatrophy associated with some hematological and developmental disorder...

CONTEXT Described originally in 1882, Gaucher's disease is the most prevalent of storage disorders. This autosomal recessive disease is caused by a defective gene responsible for coding the beta-glucosidase enzyme, essential in the hydrolysis of glucosylceramide in glucose and ceramide. The accumulation of glucosylceramide in the lysosomes of the reticuloendothelial system produces a heterogene...

Severe thrombocytopenia with bleeding is rarely reported in children with brucellosis, and recurrent epistaxis is extremely rare. Brucellosis with hemorrhage should be differentiated from viral hemorrhagic fever, malignancy, and other blood disorders. Bone marrow aspiration (BMA) is mandatory to differentiate from other blood diseases. An 8-year-old boy was admitted with recurrent epistaxis, pe...

Apart from gastroenteritis, rotavirus has been rarely implicated with some cutaneous disorders such as generalized maculo-papular exanthema, infantile acute hemorrhagic edema and Gianotti-Crosti syndrome. We report a 30-month old toddler boy who developed erythematous macular skin eruptions during the course of rotavirus gastroenteritis. To our knowledge, this is the first case in the literatur...

We describe a 51-yr-old man presenting with syncope due to torsade de pointes. The torsade de pointes was refractory to conventional medical therapy, including infusion of isoproterenol, MgSO4, potassium, lidocaine, and amiodarone. His past history, physical findings, and hormone study confirmed that QT prolongation was caused by anterior hypopituitarism that developed as a sequela of hemorrhag...

Acute promyelocytic leukemia (APL) is a unique form of acute myeloblastic leukemia, which manifests by DIVC, massive hemorrhage and hypofibrinogenemia and has a rapidly fatal outcome. Here we report a case of APL in a 38-year-old woman, who presented with an acute episode of severe menorrhagia for the first time and died due to hemorrhagic complications. The diagnosis of hematological disorders...

To discuss the current status of treatment and the key points of nursing for seminal vesiculoscopy. The indication of seminal vesiculoscopy includes relapse or refractory hemospermia, ejaculatory duct stones and ejaculatory duct obstruction while acute infection of the genitourinary tract, hemorrhagic disease, and severe organ dysfunction are primary contraindications. Key points for perioperat...

To discuss the current status of treatment and the key points of nursing for seminal vesiculoscopy. The indication of seminal vesiculoscopy includes relapse or refractory hemospermia, ejaculatory duct stones and ejaculatory duct obstruction while acute infection of the genitourinary tract, hemorrhagic disease, and severe organ dysfunction are primary contraindications. Key points for perioperat...