A 2-yr-old girl with a nonsyphilitic type of and DL titer was 1 : 1 6. Thereafter the PFC paroxysmal cold hemoglobinuria (PCH) decreased in number as the DL titer deis reported. We applied the plaque-formcreased. Eight weeks later circulating PFC ing cell (PFC) assay to the measurement of were not found but the DL titer was still Donath-Landsteiner (DL) antibody-produc1 : 1 positive. The PFC as...

Paroxysmal nocturnal hemoglobinuria (PNH) results from reduced complement regulatory proteins on hematopoietic cells, predisposing patients to intravascular hemolysis, thrombophilia, and cytopenias. Women diagnosed in pregnancy can experience significant maternofetal complications. Trials of eculizumab in PNH excluded pregnant women. Here, we report the first Canadian patient taken through preg...

The new direct oral anticoagulants such us rivaroxaban, could play an important role in the anticoagulant treatment of patients with paroxysmal nocturnal hemoglobinuria where anticoagulant treatment is complex to run, since they have shown a reduction in serious bleeding complications compared to antithrombotic therapy with classical vitamin k antagonist.