this study aimed to evaluate the clinical, histopathological and hematological effects of mesobuthus eupeus venom on chicken organs. adult chickens were subcutaneously injected with five doses of m. eupeus venom (0.5, 2, 5, 10 and 20 mg/kg; four chickens per each dose). symptoms were recorded during the experiment and blood samples were collected for hematological analysis. moreover, a complete...

background: shell is one of the most important by-products of shrimp processing methods which can potentially pollute the environment, whereas shrimp shell contain large amounts of chitin and chitosan and can be used as immune and growth stimulator in aquaculture. objectives: the purpose of present study was to investigate the effect of oral administration of chitosan extracted from litopenaeus...

Pancytopenia is a reduction in all the three cellular elements of blood; exists in adult when the hemoglobin level is less than 10g/dL, total leukocyte count is less than 4x109/L, and platelet count is less than 150x109/L.1 Pancytopenia can be due to decrease in hemopoietic cell production, ineffective haemopoiesis or peripheral destruction of the cells. The haemopoietic cell production can be ...

OBJECTIVES The aim of this prospective study was to evaluate the safety and feasibility of laparoscopic splenectomy (LS) in patients with hematological disorders of the spleen. SUBJECTS AND METHODS Between 1999 and 2001, 15 patients (11 female and 4 male), with a mean age of 30 years, underwent LS after preoperative evaluation. If difficulties were encountered in LS, one trocar site incision ...

Signs and symptoms are among the most common reasons that patients seek healthcare. Being able to identify and distinguish what constitutes a sign or symptom in practice is an important part of nurses’ clinical expertise. Symptoms are multidimensional, complex and subjective phenomena that ‘‘reflect changes in biopsychosocial functioning, sensations, or cognition of an individual.’’ In contrast...

The recent treatment of hematological malignancies appears to be unsatisfactory in child and adult patients with acute myeloid leukemia and adult patients with acute lymphocytic leukemia. A major problem in the treatment of leukemia is caused by the development of drug resistance to chemotherapeutic agents, which is already present at diagnosis or after chemotherapy as a minimal residual diseas...

We review the basic characteristics of four periodic hematological disorders (periodic auto-immune hemolytic anemia, cyclical thrombocytopenia, cyclical neutropenia and periodic chronic myelogenous leukemia) and examine the role that mathematical modeling and numerical simulations have played in our understanding of the origin of these diseases and in the regulation of hematopoiesis.

In humans, the intestinal epithelium is a single layer of cells that constitutes one of the most important barriers between internal and external environments. The so-called ‘intestinal barrier’ (IB) is a dynamic structure composed of different types of cellular junctions that can be regulated by physiological and pathological stimuli, and act as a selective barrier to antigens and pathogens. P...

Mathematical models addressing important aspects of hematological malignancies have recently facilitated an improved understanding of the involved complex biological processes and the prediction of potential targets for therapeutic approaches. These models investigate a wide spectrum of topics ranging from metabolic processes, gene regulatory networks and signal transduction up to the behavior ...