Tissue culture methods for the isolation and assay of the dengue viruses have been developed in a number of laboratories (1-7). Their aim has been to find an in vitro substitute for the suckling mouse (the usual host for these procedures). This study introduces a new method for the assay of mouse-adapted dengue viruses. Titrations and neutralization tests for serotypes 1, 2 and 4 have been cond...

Binomial Test Example: Instances of sevens as digits from a random digit generator Step 1: Formulate hypotheses. H0 : π = 1 10 , Ha : π 6= 1 10 Step 2: Obtain a test statistic. In this case, I indicated a sample of 200 random digits yielded 35 sevens. Step 3: Calculate the P -value. The P -value is the conditional probability of obtaining a test statistic at least as extreme as ours given that ...

There is continuing interest in the diagnostic potentialities of the hemagglutination test for tuberculosis described by Middlebrook and Dubos in 1948 (6) and modified by Scott and Smith in 1950 (12). This test was initially described as a useful tool to aid the clinician in the diagnosis and management of tuberculosis (9, 10, 12) . Middlebrook's emphasis has been on its usefulness in studying ...