BACKGROUND Of all human cancers, gastric carcinoma is the one of the leading causes of death. Helicobacter pylori is considered a major etiologic agent of this disease. Spontaneously occurring gastric carcinoma is a rare diagnosis in nonhuman primates. A 2011 case report documented a high incidence of gastric adenocarcinoma in a closed colony of captive sooty mangabeys (Cercebus atys). However,...

Tightly coiled bacteria are a rare cause of gastric pathology in humans and represent a mixture of species for which a zoonotic origin is suspected. Similar organisms are common inhabitants of the gastric mucosae of carnivores and pigs. It was the goal of the present study to determine the actual occurrence of each individual Helicobacter species in human, canine, and feline stomachs in order t...

Helicobacter pylori (H. pylori) infection causes a progression to atrophic gastritis and results in gastric cancer. Cytotoxin-associated gene A (CagA), major virulence factor of H. pylori, is injected into epithelial cells using the type IV secretion system. On other hand, degrade CagA an autophagy system, which strictly regulated by autophagy-related (ATG) genes. This study aimed identify SNPs...

Helicobacter pylori is a gram-negative, helical shaped and microaerophilic bacterium that colonizes in the pathogenesis of chronic gastritis, peptic ulcer disease, and gastric malignancy (Komoto et al., 1998). Since the discovery of Helicobacter pylori in 1983, strong evidence has indicated that H. pylori eradication is current standard treatment and can prevent of chronic gastritis, peptic ulc...

Helicobacter pylori colonizes the human gastric epithelium and causes diseases such as gastritis, peptic ulcers, and stomach cancer. Undecaprenyl pyrophosphate synthase (UPPS), which catalyzes consecutive condensation reactions of farnesyl pyrophosphate with eight isopentenyl pyrophosphate to form lipid carrier for bacterial peptidoglycan biosynthesis, represents a potential target for developi...

background : helicobacter pylori ( h. pylori ) infection is known as a major etiologic factor for a variety of gastroduodenal diseases. in iran, with a high rate of h. pylori infection close to 90%, numerous studies have revealed many aspects of interaction between the bacterium, mucosal surface and induction of disease outcome. the organism is genetically diverse and several virulence factors ...

Apoptosis, like Helicobacter pylori, has a long history, extending back into the 19th Century. Apoptosis was ignored or forgotten, just like H pylori, only to reemerge relatively recently. However, with the current exponential increase in the number of publications concerning H pylori, and in those written about apoptosis, it was only a matter of time before the influence of H pylori on apoptos...

Helicobacter pylori is a gram-negative bacterium that persistently colonizes more than half of the global human population. In order to successfully colonize the human stomach, H. pylori must initially overcome multiple innate host defenses. Remarkably, H. pylori can persistently colonize the stomach for decades or an entire lifetime despite development of an acquired immune response. This revi...

background: helicobacter pylori is the cause of serious diseases including gastric cancer and gastric mucosa–associated lymphoid tissue lymphoma.50% of world population is infected by this microorganism and it -based on epidemiologic studies - is mainly acquired during childhood . there is not enough evidence about prevalence of this infection in children and its risk factors so encourage us to...