Background and objective: Gastric cancer is the fourth common and the second deadliest cancer worldwide, which the major causes of its prevalence are genetic factors and the lifestyle, such as eating fast foods, physical inactivity, environmental pollution, and other natural factors. Method: This research was performed in human and animal cell bank of Iranian Biological Resource Center, and ...

Objective: Rosa beggeriana Schrenk has been consumed in Iranian traditional medicine. In contrary to its close species (e.g. R. canina), there is no data on its medicinal properties. Therefore, we explored possible cytotoxic effects of R. beggeriana against two cancer cell lines. Materials and Methods: The cytotoxic and anti-pro...

BACKGROUND The safe use in biomedicine of semiconductor nanoparticles, also known as quantum dots (QDs), requires a detailed understanding of the biocompatibility and toxicity of QDs in human beings. The biological characteristics and physicochemical properties of QDs entail new challenges regarding the management of potential adverse health effects following exposure. At certain concentrations...

AbstractFerulago angulata Boiss. known in Iran as Chavir, has some bioactive compounds having antioxidant activity. Because of its antioxidant activities, it sounded Chavir extract can be a good candidate for finding chemopreventive agents having inductive apoptosis properties on cancer cells. In this study, the cytotoxic effects and proapoptotic activities of Chavir’s leaf and flower extracts ...

objectives: 7-prenyloxycoumarins are a group of secondary metabolites that are found mainly in plants belonging to the rutaceae and umbelliferae families. this study was designed to evaluate and compare the cytotoxic and apoptotic activity of 7-prenyloxycoumarin compounds and herniarin on mcf-7, a breast carcinoma cell line. materials and methods: cells were cultured in rpmi medium and incubate...

Background CD19 CAR T- cells (Chimeric antigen receptor T that recognize CD19) present a therapeutic option for various malignant diseases based on their ability to specifically the selected tumour surface markers, triggering immune cell activation and cytokine production results in killing cancerous expressing specific markers recognized by CAR. The main effect of is adequate number with seque...

background human preimplantation embryonic cells share many similarities with cancer cells such as ability to self-renew, unlimited proliferation and maintenance of the undifferentiated state. embryo-cancer sequence a (ecsa), also known as developmental pluripotency associated-2 (dppa2), is a cancer testis antigen (cta) with unclear biological function yet. objective: ctas are expressed normall...

background: erythropoietin (epo) is a glycoprotein hormone function to regulate the production of red blood cells. deficiency of epo is known to cause anemia in chronically infected renal patients and they require regular blood transfusion. availability of recombinant epo has eliminated the need for blood transfusion and now it is extensively used for the treatment of anemia. glycosylation of e...

background: although there is convincing data in support of the effectiveness of hyperthermia in tumor therapy, the molecular mechanisms underlying the clinical effects of hyperthermia are still poorly understood. objective: to investigate natural killer (nk) cell cytotoxicity against heat-treated sw-872 and hela tumor cell lines. methods: nkg2d ligands and hla class i transcription were examin...

abstract boswellia has been widely used in traditional medicine for the treatment of different diseases such as cancer in iran. the aim of this study was to evaluate the effect of the gum methanol extract of boswellia thurifera on the viability and p53 gene expression of cultured breast cancer cells. the gum methanol extract was obtained in various concentrations using the maceration method. no...