Computer applications to storm runoff prediction have revolutionized the watershed modeling techniques. In general, a watershed is modeled as a system with inputs and outputs (Chow 1964). A system can be lumped or distributed, depending upon the spatial and temporal characteristics of the design variables used in the model. A lumped parameter ignores the variability in space. On the other hand,...

According to the hypothesis of extended cognition (HEC, hereafter), human cognitive processing extends beyond the boundary of the human organism. 2 philosophy of cognitive science; HEC is supposed to reveal something important about human beings' core cognitive faculties and, in doing so, reshape the study of human cognition. Although many authors have reacted to HEC with reasoned skepticism, 2...

Abstract Hydrological modeling is important to provide relevant hydrologic information from limited data. In this study, Hydrologic Modeling System (HEC-HMS) was used simulate the rainfall–runoff relationship for Dabus subbasin of Blue Nile Basin. Daily precipitation and stream flow data 2002 2019 were as key input model, together with soil land use/land cover data, a digital elevation model st...

Hyperelliptic curves (HEC) look promising for cryptographic applications, because of their short operand size compared to other public-key schemes. The operand sizes seem well suited for small processor architectures, where memory and speed are constrained. However, the group operation has been believed to be too complex and thus, HEC have not been used in this context so far. In recent years, ...

In this study, alendronate, the most commonly used biphosphonate for treating osteoporosis, was formulated as gastroretentive dosage form (GRDF) tablets to enhance its oral bioavailability. GRDF tablets were characterized with the effects of different molecular weights (MWs) of chitosan (CS) and hydroxyethyl cellulose (HEC) at various ratios on swelling, floating, and physical integrity. The CS...

Lymph node (LN) function depends on T and B cell compartmentalization, antigen presenting cells, and high endothelial venules (HEVs) expressing mucosal addressin cell adhesion molecule (MAdCAM-1) and peripheral node addressin (PNAd), ligands for naive cell entrance into LNs. Luminal PNAd expression requires a HEV-restricted sulfotransferase (HEC-6ST). To investigate LT alpha beta's activities i...

Matrix metalloproteinase (MMP)-2 and -9 are secreted and translocated from endometrial stromal cells to HEC-1 A cells in a steroid-dependent manner. We investigated the paracrine effect of hepatocyte growth factor (HGF) on MMPs and metalloproteinase tissue inhibitor (TIMP) expression in stromal and endometrial cancer cells, and correlated with cancer cell invasiveness in three-dimensional (3D) ...

Endometrial cancer cell lines are critical tools to investigate the molecular mechanism of tumorigenesis using the end point cell-based assay such as proliferation, cytotoxicity, apoptosis, anoikis or migration and invasion. The proper assay optimization and performance is essential for physiologically relevant results interpretation. In this study we use label-free real-time cell analysis plat...

The cell fate determinant Numb orchestrates numerous cell physiological and pathological processes and previous evidence has indicated that Numb expression is associated with tumorigenesis. The present study investigated the potential role of Numb in endometrial cancer (EC). Numb expression was compared between the normal endometrium and EC tissue by immunohistochemistry, and the protein levels...

Understanding nanoparticle diffusion within non-Newtonian biological and synthetic fluids is essential in designing novel formulations (e.g., nanomedicines for drug delivery, shampoos, lotions, coatings, paints, etc.), but is presently poorly defined. This study reports the diffusion of thiolated and PEGylated silica nanoparticles, characterized by small-angle neutron scattering, in solutions o...