OBJECTIVE To determine whether patients with congestive heart failure on different beta adrenoreceptor blocking drugs have similar haemodynamic responses to dobutamine. DESIGN Single centre, single blind, randomised, two period crossover study comparing carvedilol with metoprolol CR/XL. PATIENTS Ten patients with stable chronic congestive heart failure (ejection fraction < 40%) on chronic t...

Anthrax lethal toxin (LeTx) and edema toxin (EdTx) have been shown to alter hemodynamics in the rodent model, while LeTx primarily is reported to induce extensive tissue pathology. However, the rodent model has limitations when used for comparison to higher organisms such as humans. The rabbit model, on the other hand, has gained recognition as a useful model for studying anthrax infection and ...

background: pet/ct imaging using [18f]-fdg is utilized in clinical oncology for tumor detecting, staging and responding to therapy procedures. essential consideration must be taken for radiation staff due to high gamma radiation in pet/ct and cyclotron center. the aim of this study was to assess the staff exposure regarding whole body and organ dose and to evaluate environment dose in pet/ct an...

background: we have validated the monitor unit calculations from a commercially available treatment planning system (tps) for three intensity modulated radiotherapy (imrt) planning techniques for tangential breast irradiation by using ionization chamber measurements. materials and methods: treatment plans were generated for forty-two breast patients by a forward planned field in field technique...

BACKGROUND/AIM There is no information on the dose-response relationship of curcumin on the hemodynamic variables of the heart at the organ level in isolated perfused rat hearts. We aimed to investigate the effects and mechanisms of curcumin on the hemodynamic variables of isolated perfused rat hearts. MATERIALS AND METHODS Rats were randomly divided into 9 groups. The isolated rat heart was ...

PURPOSE To evaluate cardiac doses in breast cancer patients with stage II/III treated with 4-field radiotherapy based on computed tomography (CT) dose planning. METHODS AND MATERIALS Based on archived CT images, whole heart and cardiac chamber radiation doses were analyzed in 216 (111 left-sided and 105 right-sided) mastectomized or lumpectomized breast cancer patients treated at a single ins...

Tirzepatide, a glucose-dependent insulinotropic polypeptide receptor and glucagon-like peptide-1 agonist has recently been approved by FDA for type 2 diabetes in adults as single dose weekly. Tirzepatide is phase 3 development with obesity or overweight weight-related comorbidity. also under evaluation treatment of non-alcoholic steatohepatitis, heart faialure obstructive sleep apnea.

Vasoactive intestinal polypeptide (VIP) is implicated in the modulation of vagal effects on the heart rate. In this study, the impact of acute and chronic atropine administration on VIP levels in rat heart atria was investigated in relation to heart rate in the course of vagus nerves stimulation. Anaesthetised control and atropinised (10 mg/kg/day for 10 days) rats pretreated with metipranolol ...