The cause of flushing attacks in patients with carcinoid syndrome is unknown. In a subgroup of patients (many ofwhom have metastatic gastric carcinoid tumours) histamine excretion is frequently and consistently raised.45 Two reports have shown significant reductions in both frequency and duration offlushing attacks during combined treatment with H, and H2 receptor antagonists in two patients wi...

BACKGROUND Typical carcinoid syndrome is characterized by flushing, abdominal pain and diarrhea and occurs in <10 % of carcinoid tumor patients. Very rarely, initial signs include skin manifestations. Our purpose is to highlight cutaneous manifestations in the diagnosis and assessment of a patient with atypical manifestation of type I gastric carcinoid tumor. CASE PRESENTATION A 50-year-old w...

A patient with a carcinoid tumour and a history suggestive of carcinoid syndrome, but with no biochemical evidence in support, had a cardiovascular collapse during an anaesthetic with propofol and suxamethonium. Subsequent investigations suggested an anaphylactoid reaction to suxamethonium, but there were features in common with a carcinoid crisis. The necessity for a second anaesthetic soon af...

Metastatic primary testicular carcinoid tumor remains a very rare condition. We report the first case of metastatic primary testicular carcinoid tumor where along retroperitoneal lymph node dissection excision of the Inferior Vena Cava was also performed. The rarity is further emphasised by the presence of a contralateral testicular dermoid cyst. Given the features of the tumor were not in keep...

Cushings’s syndrome due to ectopic adrenocorticotrophin (ACTH) secretion was first described nearly a century ago by Hurst Brown. Bronchial carcinomas, usually bronchial carcinoids, were the first to be described and continue to be the leading cause of the ectopic ACTH syndrome; however, thymic carcinoids account for approximately 10% of cases. The Zollinger Ellison syndrome, excessive gastrin ...

The pathogenesis of flushing attacks in patients with malignant carcinoid tumors is attributed to the direct pharmacologic effect of excessive amounts of circulating serotonin. It was hoped that potent serotonin antagonists might relieve symptoms of the carcinoid syndrome in the inoperable patient. The nature of flushing attacks was studied in carcinoid patients and the influence thereon of 3 s...

Carcinoid tumors are slow growing neoplasms of neuro-endocrine tissues arising from enterochromaffin cells and although rare can create serious problems during the surgery due to myriad clinical manifestations and perioperative complications. A slow growing tumor, it remains asymptomatic and is mostly found coincidentally intraoperative. Tumor secretes mediators which, if, bypass the hepatic me...