INTRODUCTION A significant number of mania patients fail to respond to current pharmacotherapy, thereby there is need for novel augmentation strategies. The results of some early studies showed the effectiveness of cholinomimetics in the treatment of mania. One open case series suggested the efficacy of donepezil in the treatment of bipolar disorder. Our aim was to explore whether an oral choli...

The term ‘treatment-resistant schizophrenia’ is broadly used to describe people with a diagnosis of schizophrenia who do not respond adequately to antipsychotic treatment and continue to have residual symptoms and/or poor psychosocial functioning. Although treatment-resistant schizophrenia is a familiar concept, various definitions and criteria have been proposed over the years to define it as ...

this policy brief discusses preventive care benefits and cost-sharing included in health insurance provisions of the affordable care act (aca) legislation and highlights some consequences to americans and the country in terms of healthcare costs and value.

Diagnostic and Symptom Quantification Procedures Masters or Doctoral-level clinicians conducted diagnostic evaluations and clinical ratings. Diagnoses were confirmed by consensus conference. Among a random sample of 10 subjects, the level of inter-rater agreement for diagnosis was high, with kappa = 0.86. Symptoms were quantified with the Brief Psychiatric Rating Scale (BPRS), Scale for the Ass...

Although alcohol screening and brief intervention (SBI) reduces drinking in primary care patients with unhealthy alcohol use, incorporating SBI into clinical settings has been challenging. We systematically reviewed the literature on implementation studies of alcohol SBI using a broad conceptual model of implementation, the Consolidated Framework for Implementation Research (CFIR), to identify ...

The prevalence of alcohol abuse among patients treated in accident and emergency departments (A&E) is considered as substantial. This paper is a narrative review of studies investigating the effectiveness of brief interventions (BI) for hazardous and harmful alcohol consumption in A&E. A&E departments in hospitals (and other health care infrastructures) are commonly the place where serious cons...

BACKGROUND Health care providers do not routinely carry out brief counseling for tobacco cessation despite the evidence for its effectiveness. For this intervention to be routinely used, it must be brief, be convenient, require little investment of resources, require little specialized training, and be perceived as efficacious by providers. Technological advances hold much potential for address...

BACKGROUND Alcohol abuse comes with risks for increased morbidity and mortality among patients with HIV. This study aims to determine the prevalence of alcohol use and other risk factors in a sample of primary care patients with HIV in South Africa and to assess a brief intervention to reduce the use of alcohol in this group. METHODS/DESIGN A single-blinded randomized controlled trial is desi...

The term ‘treatment-resistant schizophrenia’ is broadly used to describe people with a diagnosis of schizophrenia who do not respond adequately to antipsychotic treatment and continue to have residual symptoms and/or poor psychosocial functioning. Although treatment-resistant schizophrenia is a familiar concept, various definitions and criteria have been proposed over the years to define it as ...