Histone deacetylase (HDAC) inhibitors (HDI) induce endoplasmic reticulum (ER) stress and apoptosis, while promoting autophagy, which promotes cancer cell survival when apoptosis is compromised. Here, we determined the in vitro and in vivo activity of the combination of the pan-HDI panobinostat and the autophagy inhibitor chloroquine against humanestrogen/progesterone receptor andHER2 (triple)-n...

OBJECTIVE To analyse the evolution of the frequency of type 2 diabetes (T2D) and its relationship to eating patterns in Mexico from 1961 to 2013, and the Gini coefficient, Human Development Index (HDI) and Gross Domestic Product (GDP). Mexico ranked sixth in world prevalence of diabetes in 2015 with an estimated 11.4 million Mexicans affected. METHOD Using data from the Balance Sheets Food pu...

BACKGROUND Migrants with mental hospital orders according to section 63 of the German criminal code are overrepresented in relation to their numbers in the general population. Subgroups originating from certain world regions are diagnosed with schizophrenia at a much higher rate than others. In the present literature, there is a strong evidence for a substantial correlation between migration, s...

This paper addresses the path selection problem arising in multi-hop sensor networks, e.g., for Smart Grids. In such scenarios, a communication system consisting of multiple multi-hop paths with time-varying hops connects a source and destination. To avoid interference and keep energy consumption low, the source can only send on one path and accrue a reward determined by the state of the traver...

304 Rev Assoc Med Bras 2010; 56(3): 304-8 *Correspondence: Rua Antônio da Veiga, 140 Sala L-002 Victor Konder Blumenau-SC, Brazil CEP: 89012-900 Phone: (+ 55 47) 33210277 deisivargas@furb.br AbstrACt Objective. The objective of this study was to analyze the secular trend of growth in height of military recruits enlisted in Blumenau and correlate it with the HDI index. MethOds. This was a cross-...

3 List of Tables 4 I. Methodology and Data Source 6 II. Analysis of data using Method I 16 III. Estimates of HDI for year 2001 in Rural AP based on Method III 27 Summary and Conclusions 37

OBJECTIVES One of the most common head and neck cancers is nasopharynx cancer. Knowledge about the incidence and mortality of this disease and its distribution in terms of geographical areas is necessary for further study and better planning. Therefore, this study was conducted with the aim of determining the incidence and mortality rates of nasopharynx cancer and its relationship with the Huma...

Abstract We aimed to investigate how lethal police violence (LPV) in the City of São Paulo (CSP), Brazil, is associated with socioeconomic development when we consider victims’ place residence and locations fatal injuries. The spatial distribution rate (LPVR) its association human index (HDI) was investigated using Moran’s I (Global Bivariate Local). Between 2014 2015 found 403 victims Health d...

We use annual data on over 150 countries between 2005 and 2018 to look at the relationship subjective well-being (both cognitive affective) Human Development Index (HDI). The HDI appears be more closely related than affective well-being. also consider relationships three components (the Income, Health, Education Indices) well-being, find that, average, Income has strongest predictive power. Imp...