نتایج جستجو برای: hcv genome

تعداد نتایج: 249841  

Journal: :Journal of virology 1996
A Lieber C Y He S J Polyak D R Gretch D Barr M A Kay

Hepatitis C virus (HCV), a positive-strand RNA virus, is the major infectious agent responsible for causing chronic hepatitis. Currently, there is no vaccine for HCV infection, and the only therapy for chronic hepatitis C is largely ineffective. To investigate new genetic approaches to the management of HCV infection, six hammerhead ribozymes directed against a conserved region of the plus stra...

Journal: :Science 1999
V Lohmann F Körner J Koch U Herian L Theilmann R Bartenschlager

An estimated 170 million persons worldwide are infected with hepatitis C virus (HCV), a major cause of chronic liver disease. Despite increasing knowledge of genome structure and individual viral proteins, studies on virus replication and pathogenesis have been hampered by the lack of reliable and efficient cell culture systems. A full-length consensus genome was cloned from viral RNA isolated ...

Journal: :The Southeast Asian journal of tropical medicine and public health 2009
Prapan Jutavijittum Yupa Jiviriyawat Amnat Yousukh Chansom Pantip Niwat Maneekarn Kan Toriyama

The purpose of this study was to determine the prevalence and distribution of HCV genotypes among voluntary blood donors in northern Thailand. From 1998 to 2000, 167 serum samples which tested positive for anti-HCV antibodies in the screening of voluntary blood donors from 5 provinces in northern Thailand were selected for genotyping. Viral RNA was extracted from the sera. The core-E1 region of...

Journal: :hepatitis monthly 0
faraz salehi moghadam gastroenterology and liver diseases research center, shahid beheshti university of medical sciences, tehran, ir iran; department of microbiology, faculty of biological sciences, shahid beheshti university, tehran, ir iran seyed reza mohebbi gastroenterology and liver diseases research center, shahid beheshti university of medical sciences, tehran, ir iran; gastroenterology and liver diseases research center, shahid beheshti university of medical sciences, tehran, ir iran. tel.: +98-2122432514, fax: +98-2122432515, email: [email protected] seyed masoud hosseini department of microbiology, faculty of biological sciences, shahid beheshti university, tehran, ir iran behzad damavand gastroenterology and liver diseases research center, shahid beheshti university of medical sciences, tehran, ir iran mohammad reza zali gastroenterology and liver diseases research center, shahid beheshti university of medical sciences, tehran, ir iran

results phylogenetic analysis of the partial ns5b region demonstrated the relatedness of isolate fsm165 to the new subtype reported from iran in 2006. moreover, some core/e1 and ns5b sequences that had a high level of similarity with fsm165 isolate were found through searching the hcv database. these sequences were previously either misclassified or could not be accurately classified. phylogene...

A Ahmadi-Vasmehjani, A Samie , M Doosti , M Ghaderi , R Baharlou , S Jahanabadi , SD Mousavi-Nasab , SMA Hashemi ,

Background and Aims: Torque teno virus (TTV) is a DNA virus that isolated from the serum of a Japanese patient without A-G transfusion-transmitted hepatitis and other etiology. TTV is detectable in plasma and peripheral blood mononuclear cells, different body fluids and secretions such as stools, saliva, semen, vaginal fluid. The genome exhibits high diversity that has enabled the determination...

Journal: :Journal of virology 2001
W D Zhao E Wimmer

Internal ribosomal entry sites (IRESs) of certain plus-strand RNA viruses direct cap-independent initiation of protein synthesis both in vitro and in vivo, as can be shown with artificial dicistronic mRNAs or with chimeric viral genomes in which IRES elements were exchanged from one virus to another. Whereas IRESs of picornaviruses can be readily analyzed in the context of their cognate genome ...

پایان نامه :وزارت علوم، تحقیقات و فناوری - دانشگاه پیام نور - دانشگاه پیام نور استان تهران - دانشکده علوم پایه 1390

مقدمه و هدف پژوهش: عفونت هپاتیت c معضل بهداشتی مهمی در سراسر دنیا می باشد و در سراسر دنیا بطور شایع رخ می دهد. فراوانی عفونت توام hcv و hiv در افراد معتاد تزریقی بالا بوده و بین 10 تا 50% در مناطق مختلف جغرافیائی متغیر است. سیر پیشرفت بیماری به سمت سیروز در بیماران عفونت توامhiv/hcv بیشتر از بیماران مبتلا به عفونت تنهای hcv است و در ضمن پاسخ به درمان در بیماران مبتلا به عفونت توام hiv/hcv کمتر ...

Journal: :Hepatology 2004
Jinah Choi Ki Jeong Lee Yanyan Zheng Ardath K Yamaga Michael M C Lai Jing-Hsiung Ou

Hepatitis C virus (HCV) is a positive-stranded RNA virus that causes severe liver diseases, such as cirrhosis and hepatocellular carcinoma. HCV uses an RNA-dependent RNA polymerase to replicate its genome and an internal ribosomal entry site to translate its proteins. HCV infection is characterized by an increase in the concentrations of reactive oxygen species (ROS), the effect of which on HCV...

Journal: :The Journal of infectious diseases 2010
Sandra Ciesek Martina Friesland Jörg Steinmann Britta Becker Heiner Wedemeyer Michael P Manns Jochen Steinmann Thomas Pietschmann Eike Steinmann

BACKGROUND In the absence of a cell culture system for propagation of the hepatitis C virus (HCV), the antiviral activity of disinfectants against HCV was extrapolated from studies with the bovine viral diarrhea virus. The recent development of an HCV infection system allowed the direct assessment of environmental stability and susceptibility to chemical disinfectants. METHODS Studies were pe...

Journal: :Virus research 2012
Hiroe Sejima Kyoko Mori Yasuo Ariumi Masanori Ikeda Nobuyuki Kato

Persistent hepatitis C virus (HCV) infection frequently causes hepatocellular carcinoma. However, the mechanisms of HCV-associated hepatocarcinogenesis and disease progression are unclear. Although the human hepatoma cell line, HuH-7, has been widely used as the only cell culture system for robust HCV replication, we recently developed new human hepatoma Li23 cell line-derived OL, OL8, OL11, an...

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