Background.  Perinatally acquired hepatitis C virus (HCV) is the main source of pediatric HCV infection. However, the best time for initiation of screening and follow up of these infants is still unknown. Analysis of the clinical data of infants born to HCV-infected mothers, transmission rates, and pathway of HCV testing could be important for optimization of their management. Methods.  Childre...

The majority of hepatitis C virus (HCV) and human immunodeficiency virus (HIV) coinfection occurs among persons who inject drugs. Rapid improvements in responses to HCV therapy have been observed, but liver-related morbidity rates remain high, given notoriously low uptake of HCV treatment. Advances in HCV therapy will have a limited impact on the burden of HCV-related disease at the population-...

The hepatitis C virus (HCV) neutralizing antibody (nAb) response in 37 subjects with HCV monoinfection and 37 HCV-infected subjects with well-controlled human immunodeficiency virus (HIV) infection was evaluated using a focus reduction neutralization assay. HCV nAb levels were retrospectively studied in both groups of patients, who were matched on the basis of sex, age, and HCV genotype. The me...

Assay Manufacturer Method Detection limit or dynamic range (IU/mL) Qualitative HCV RNA dection assays AmplicorTM HCV 2.0 Roche Molecular System Manual RT-PCR 50 Cobas AmplicorTM HCV 2.0 Roche Molecular System Semi-automated RT-PCR 50 VersantTM HCV Siemens Health Care Diagnostics Semi-automated TMA 10 Quantitative HCV RNA detection assays AmplicorTM HCV Monitor Roche Molecular System Manual RT-P...

conclusions the overall prevalence of hbv and hcv was 1.16% and 1.42%, respectively. the incidence of hcv infection among the pregnant women was higher than that of hbv infection. materials and methods the cross-sectional study took place between july 2013 and april 2014. a total of 10,288 samples were collected from pregnant women living in different areas of the peshawar district. the samples...

background and aims: chronic hepatitis c is one of the most important etiologies of cirrhosis and hepatocellular carcinoma worldwide. clinical condition of hepatic patients and the outcome of chemotherapy are under impact of hepatitis c virus (hcv) genotypes. therefore, hcv genotyping is important for prediction of success of chemotherapy and progression of liver diseases. methods: in this arti...

INTRODUCTION .......................................................................................................................................................223 GENOMIC ORGANIZATION OF HCV..................................................................................................................223 GENOMIC HETEROGENEITY AND CLASSIFICATION SYSTEMS ......................................

OBJECTIVE To determine patient and dialysis services-related factors associated with seroconversion of hepatitis C virus (HCV) in hemodialysis (HD) patients. STUDY DESIGN Cross-sectional study. PLACE AND DURATION OF Department Nephrology, Mayo Hospital, King Edward Medical University (KEMU), Lahore, from January to December, 2018. METHODOLOGY All patients on regular HD for more than three month...

BACKGROUND An HIV-1 and HCV NAT blood screening assay (Procleix HIV-1/HCV, Gen-Probe, Inc.) simultaneously detecting HIV-1 and HCV RNA) has been implemented. Donor plasma samples reactive in the Procleix HIV-1/HCV assay are tested with the HIV-1 and HCV discriminatory assays to resolve whether HIV-1 RNA, HCV RNA, or both are present. STUDY DESIGN AND METHODS To determine the specificity of th...

Hepatitis C virus (HCV) chronically infects approximately 170 million people worldwide, with an increased risk of developing cirrhosis and hepatocellular carcinoma. The study of HCV replication and pathogenesis has been hampered by the lack of an efficient stable cell culture system and small-animal models of HCV infection and propagation. In an effort to develop a robust HCV infection system, ...