OBJECTIVES The goal of this study was to investigate the relationship between hematocrit (Hct) and left ventricular mass index (LVMI) and LV hypertrophy (LVH) in subjects without known hypertension or cardiovascular disease in the Framingham Heart study. BACKGROUND Anemia may be an independent risk factor for cardiovascular disease in the general population. One potential explanation for this...

PURPOSE This investigation quantified the effect of changes in plasma osmolality on the measurement of hematocrit (Hct) and the implications for the subsequent use of these data to calculate changes in plasma volume and application to the World Anti-Doping Agency Athlete Biological Passport. METHODS Two groups of eight male volunteers visited the laboratory after an overnight fast. In study 1...

Several studies have shown that allogeneic hematopoietic cell transplantation (HCT) in first complete remission (CR1) of AML reduces the risk of relapse and improves relapse-free survival in intermediateand poor-risk AML. Benefits in (overall) survival are less obvious. One possible explanation is that following the occurrence of relapse, previous receipt of allogeneic HCT in CR1 is associated ...

objective(s):protective effects of diuretics, particularly of hydrochlorothiazide (hct), for the development of seizure attacksepilepsy have been described in vivo. however, itsthe mechanism of action of hct is unknownneeds to be elucidated. materials and methods: extracellular field potentials were recorded from the ca1- and ca3-subfields of the hippocampus of rats. epileptiform discharges wer...

Abstract Numbers of Hematopoietic cell transplantation (HCT) in Europe and collaborating countries continues to rise with 48,512 HCT 43,581 patients, comprising 19,798 (41%) allogeneic 28,714 (59%) autologous, reported by 700 centers 51 during 2019. Main indications were myeloid malignancies 10,764 (25%), lymphoid 27,895 (64%), nonmalignant disorders 3173 (7%). A marked growth CAR-T cellular th...

Acute renal failure (ARF) is a common life-threatening complication after myeloablative allogeneic hematopoietic cell transplantation (HCT). Nonmyeloablative HCT aims to eradicate the malignancy with graft-versus-tumor effect, rather than with high doses of chemoradiotherapy. It may be anticipated that a lower risk of ARF exists in nonmyeloablative HCT as a result of the milder preconditioning ...

Autologous HCT For individuals who have Hodgkin lymphoma who receive autologous HCT as initial therapy, the evidence includes randomized controlled trials (RCTs). Relevant outcomes are overall survival, disease-specific survival, change in disease status, morbid events, and treatment-related mortality and morbidity. RCTs of autologous HCT as first-line treatment have reported that this therapy ...

OBJECTIVES Prior studies have found that cardiac surgery patients receiving blood transfusions are at risk for increased mortality and morbidity following surgery. It is not clear whether this increased risk occurs across all haematocrit (HCT) levels. The goal of this study was to compare operative mortality in propensity-matched cardiac surgery patients based on stratification of the preoperat...

BACKGROUND Uptake of couples' HIV counseling and testing (couples' HCT) services remains largely low in most settings. We report the effect of a demand-creation intervention trial on couples' HCT uptake among married or cohabiting individuals who had never received couples' HCT. METHODS This was a cluster-randomized intervention trial implemented in three study regions with differing HIV prev...