BACKGROUND Several studies have shown that the pathophysiology of homozygous sickle cell anaemia (SCA) results in a myriad of metabolic, nutritional, haematological and clinical effects that interact with other co-morbid factors to determine the quality of life and life expectancy of afflicted patients. Because of its critical roles in nutrition and metabolism, inflammation, haematopoiesis and ...

there is evidence indicating that pomegranate juice contains many of the essential properties necessary to retain cell viability and cell proliferation. these properties indicate that pomegranate juice is a suitable storage medium for avulsed teeth. however, this idea has not yet been tested. in this study, the capacity of pomegranate juice (pj) as a storage medium for retaining avulsed teeth w...

In order to provide the best long-term prognosis for a tooth that is to be replanted intentionally, the tooth must be kept out of the socket for the shortest period possible [4], and the extraction of the tooth should be atraumatic to minimise damage to the cementum and the periodontal ligament [5]. The periodontal ligament attached to the root surface should be kept moist in saline, Hank’s Buf...

7. Agbaraji VO, Scott RB, Leto S, Kingslow LW. Fertility studies in sickle cell disease: semen analysis in adult male patients. Int J Fertil 1988;33:347-352. 8. Abudu EK, Akanmu SA, Soriyan OO, Akinbami AA, Adediran A, Adeyemo TA, Okany CO. Serum testosterone levels of HbSS (sickle cell disease) male subjects in Lagos, Nigeria. BMC Res Notes 2011;4:298. 9. Gharwan H, Neary NM, Link M, Hsieh MM,...

A 12-year-old boy with HbSS sickle cell disease (SCD) was admitted with an acute febrile illness and developed overt stroke 3 days later. Plasma glial fibrillary acidic protein levels were elevated, as compared to pediatric controls, 32 h prior to the clinical diagnosis of stroke, peaked immediately prior to the exchange transfusion, and remained elevated 1 year later despite chronic transfusio...

until later determination was added. The perfusate was stored at -20 “C and TxB by radioimmunoassay. Perfusion pressure was kept at 7 mm Hg and the A&n vessel segments from each animal were divi B ulsatile%nean flow at 90 ml/mm. The four ed into four groups with pH at either 6.0, 7.0, 7.4 or 7.8. The HBSS stock solution with a pH of 6.3 was titrated with NaOH or HCl to reach the desired pH. The...

We investigated 57 patients with sickle cell anaemia (HbSS) and bone and joint changes. Osteonecrosis simulating a wide range of conditions was a common radiological feature, and osteomyelitis occurred in 61% of cases. Salmonella species were the commonest causative organisms, occurring in 71% of patients with osteomyelitis, although salmonella septic arthritis occurred in only two. The distinc...

In this study, a composite of bioactive glass (BG) and cordierite (BG-cord) was proposed to increase the strength bioactivity BG. Both BG were separately synthesized with method melting, then, they used fabricate BG-cord variation sintering temperature (600 1000 °C). The highest diametral tensile (DTS=30.54 MPa) shown by at 925 ºC. Bioactivity tests conducted soaking in Hank’s balanced salt sol...

Sickle cell disease (SCD) is a hereditary blood disorder characterized by abnormally shaped red cells. SCD frequently exhibits multisystemic manifestations including oral and craniofacial disorders. Craniofacial features such as maxillary protrusion and more forward growth of the mandible with significantly retruded maxillary and mandibular incisors are common. When a patient with Sickle Cell D...