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In this study, we identified and characterized the hot luminous UV-bright stars in globular cluster NGC 2808. We combined data from Ultra Violet Imaging Telescope (UVIT) on board Indian space satellite AstroSat with Hubble Space UV Globular Cluster Survey for central region (within ) Gaia ground-based optical photometry outer parts of cluster. constructed UV-optical color–magnitude diagrams, co...

To clarify the role of gammaN-terminal Gly, gamma5 Glu, and gamma143 Ser in 2,3-biphosphosphoglycerate (BPG) binding to fetal hemoglobin (Hb F), we engineered and produced normal human Hb F and two Hb F variants (Hb F gammaG1V, gammaS143H, and Hb F gammaG1V, gammaE5P, gammaS143H) using a yeast expression system and then compared their oxygen-binding properties with those of native human Hb F an...

background: hemoglobin (hb) and hematocrit (hct) have been used routinely in the diagnosis of neonatal anemia and polycythemia.   objective: to measure the cord blood hb and hct and to determine their association with maternal hb and hct.   methods : 170 healthy neonates born through normal vaginal delivery with gestation age of 37-42 wks and birth weight of 2.5-4 kg, and their mothers were inc...

Ilona B. Bruinsma,1,2 Mieke de Jager,1,2 Anna Carrano,5 Alexandra A. M. Versleijen,1,2 Robert Veerhuis,6 Wilbert Boelens,3 Annemieke J. M. Rozemuller,5 Robert M. W. de Waal,4 and Marcel M. Verbeek1,2 Departments of 1Neurology and Alzheimer Centre, 2Laboratory Medicine, 3Biomolecular Chemistry and Nijmegen Centre for Molecular Life Sciences, and 4Pathology, Donders Institute for Brain, Cognition...

Dissociation of both human deoxyhemoglobin (deoxy-Hb) and carboxyhemoglobin (HbCO) at alkaline pH exposes previously buried tyrosine residues to the environment and alters their PK. Subunit association and dissociation of deoxy-Hb and HbCO can be followed through spectral changes which arise from these changes in tyrosine ionization above pH 10.0. The difference spectrum of the dissociation rea...

Human hemolysate contains several minor components designated Hb A,,, Hb Alh, Hb A,,, which are post-translational modifications of the major hemoglobin component A,,. Individuals with diabetes mellitus have elevated levels of Hb A,,, a hemoglobin modified with a glucose moiety at the NH, terminus of each /3 chain. A new chromatographic technique using Bio-Rex 70 is described which not only all...

To further understand determinants for Hemoglobin (Hb) S polymerization, as well as the inhibitory mechanism of Hb F on Hb S polymerization, Hb F variants containing Val-* (Hb F yE6V) or Val-*, Thr-y87 (Hb F yE6V. yQ87Tj were expressed in yeast. The oxy form of Hb F yE6V was about 10-fold less stable to mechanical agitation than native oxy Hb F, which is similar to stability differences compari...

OBJECTIVES Implantation failure is an obstacle in assisted reproduction techniques (ART). Calcitonin is a molecules involved in uterine receptivity and embryo implantation. Melatonin can promote embryo quality and improve implantation. This study examines the effect of pretreatment of blastocysts with melatonin and calcitonin on heparin binding-epidermal growth factor (HB-EGF) expression in mur...