Biochemical regulatory networks governing diverse cellular processes such as stress-response, differentiation and cell cycle often contain coupled feedback loops. We aim at understanding how features of feedback architecture, such as the number of loops, the sign of the loops and the type of their coupling, affect network dynamical performance. Specifically, we investigate how bistability range...

In this work, we study the volume ratio of the projective tensor products `p ⊗π `q ⊗π `r with 1 ≤ p ≤ q ≤ r ≤ ∞. We obtain asymptotic formulas that are sharp in almost all cases. As a consequence of our estimates, these spaces allow for a nearly Euclidean decomposition of Kašin type whenever 1 ≤ p ≤ q ≤ r ≤ 2 or 1 ≤ p ≤ 2 ≤ r ≤ ∞ and q = 2. Also, from the Bourgain-Milman bound on the volume rat...

127 Restoration of vocal function with laryngeal framework surgery (laryngoplastic phonosurgery) was introduced at the beginning of the 20th century. Today, these procedures have emerged as the dominant surgical management approach for the treatment of the aerodynamic incompetence and acoustic deterioration associated with vocal fold paralysis/paresis. Other indications include cancer defects, ...

Telomeres are specialized nucleoprotein complexes that comprise the ends of linear chromosomes. Human telomeres end in a short, single-stranded DNA (ssDNA) overhang that is recognized and bound by two telomere proteins, POT1 and TPP1. Whereas POT1 binds directly to telomere ssDNA, its interaction with TPP1 is essential for localization of POT1 to the telomere. TPP1 also provides enhanced bindin...

Observers viewed two side-by-side arrays each of which contained three yellow Munsell papers, three blue, and one neutral Munsell. Each array was illuminated uniformly and independently of the other. The neutral light source intensities were 1380, 125, or 20 lux. All six possible combinations of light intensities were set as illumination conditions. On each trial, observers were asked to rate t...

Flexible Alternating Current Transmission Systems (FACTS) devices have been used for several targets in power system, one of the main contributions of the devices is improving operation conditions. In this paper, two types of these devices have been placed to raise voltage profile, minimizing system loss and arising loadability. The suggested FACTS devices are: Unified Power Flow Controller (UP...

Abstract Many nations incentivize retirement saving by letting workers defer taxes on pension contributions, imposing them when retirees withdraw their funds. Using a dynamic life-cycle model, we show how ‘Rothification’ – that is, taxing 401(k) contributions rather than payouts alters saving, investment, consumption, and Social Security claiming patterns. We find instead of withdrawals leads t...

diet of patient who has tolerated kidney transplantation is differing from the past. knowing about this subject, help patient choose proper diet. patient may be has many questions about his/her diet that must be considered. do you need to special diet? yes, after kidney transplantation, diet playing important role. you understanding that attention to diet after transplantation are easier than d...