The synthesis of a novel dihydropyridine derivatives bearing dimedone as an excellent precursor has been achieved by applying three component Hantzsch condensation. The newly synthesized compounds were characterized by IR, NMR, Mass spectra and also by C, H, N analyses. All synthesized compounds undergo docking studies and biological screening for antimicrobial activity against Gram-positive ba...

An efficient synthesis of polyhydroquinoline derivatives was reported via four-component coupling reactions of aldehydes, 1,3-dicarbonyl ketones (dimedone or 1,3-cyclohexanedione), ethyl acetoacetate or methyl acetoacetate and ammonium acetate in the presence of a catalytic amount of nanocrystalline TiO2 under solvent free conditions. The reported method is mild, rapid and has the advantages su...

The de novo synthesis of pyridines from smaller molecules has attracted a lot of interest since pyridine is one of the most important heterocyclic structural motifs in numerous areas of organic chemistry. Many developed syntheses, such as the Kr hnke or the Hantzsch reaction, rely on condensation reactions of smaller molecules, but a number of synthetic approaches including cycloaddition reacti...

hantzsch 1 ,4- dihy&opyridines; are rapidly oxidized to the corresponding pyridine derivatives using zinc chlorochromate nonahydrate [zn(c1cro ) .9h o] in dichloromethane at room temperature. in addition to aromatization, no loss of the 4- substituent is observed

A new series of 2-hydrazone-thiazoline-4-ones 3a-d and 2-hydrazone-5arylidene-thiazoline-4-ones 4a-h, 5a-f and 6a-b were synthesized starting from various thiosemicarbazones by the Hantzsch condensation with chloroacetic acid. The newly synthesized compounds were screened for their antimicrobial activity against 4 strains of bacteria: Staphylococcus aureus (ATCC 29213), Bacillus subtilis (ATCC ...

New and known arylidene-hydrazinyl-thiazole derivatives have been synthesized by a convenient Hantzsch condensation. All compounds were evaluated for their in vitro cytotoxicity on two carcinoma cell lines, MDA-MB231 and HeLa. Significant antiproliferative activity for 2-(2-benzyliden-hydrazinyl)-4-methylthiazole on both MDA-MB-231 (IC50: 3.92 µg/mL) and HeLa (IC50: 11.4 µg/mL) cell lines, and ...