A simple and mild one-pot three-component reaction for the preparation 1,4-dihydropyridines has been developed from various aldehyde substrates, 1,3-dicarbonyl compounds (dimedone) and ammonium acetate (Hantzsch method) in the presence of a catalytic amount of phospho sulfonic acid (PSA) as an efficient and heterogeneous solid acid in EtOH at room temperature. Preparation of PSA is straightforw...

A carbene-catalyzed reductive coupling reaction of carboxylic esters and substituted Hantzsch is disclosed. Key steps this include one-electron reduction a carbene catalyst-bound acyl azolium intermediate to generate the corresponding radical for subsequent alkylation reactions. The promoted by irradiation with visible light without involvement transition-metal photocatalysts. Mechanistic studi...

Organic-inorganic hybrid materials provide a desirable platform for the development of novel functional materials. Here, we report one-pot synthesis mesoporous nanospheres by in-situ sol-gel condensation tetraethoxysilane around surfactant micelle-confined nano covalent organic polymer (nanoCOP) colloids. The containing nanoCOPs uniformly distributed in mesosilica network, inherited visible lig...

Polyaza-heterocycles show a plethora of biological properties and represent significant percentage clinically used drugs. However, the imizado[1,2-a]pyrimidine ring system needs more attention in terms pharmaceutical applications. Herein, we report sequence involving an aldolic condensation/bromination/Hantzsch reaction to construct series 2-alkenylimidazo[1,2-a]pyrimidines for exploring their ...

A simple and mild one-pot three-component reaction for the preparation 1,4-dihydropyridines has been developed from various aldehyde substrates, 1,3-dicarbonyl compounds (dimedone) and ammonium acetate (Hantzsch method) in the presence of a catalytic amount of phospho sulfonic acid (PSA) as an efficient and heterogeneous solid acid in EtOH at room temperature. Preparation of PSA is straightforw...

Cytochrome P-450 (CYP) isoforms responsible for the cleavage of Hantzsch pyridine ester at the 3-position of pranidipine were studied in vitro using cDNA-expressed human CYP enzymes. CYP1A1, 1A2, 2D6, and 3A4 cleaved the ester with a catalytic activity of 5.5, 0. 93, 13.1, and 22.4 nmol/30 min/nmol P-450, respectively. CYP2A6, 2B6, 2C8, 2C9, 2C19, and 2E1 were not involved in the de-esterificat...