Antibodies against cytochromes P-450a, P-450b + P450e, P-450c, and P-450d and epoxide hydrolase were utilized in a radial immunodiffusion assay to measure the concentration of these inducible, xenobiotic-metabolizing enzymes in liver microsomes from rats treated with Aroclor 1254, fireMaster BP-6, or one of 41 individual polychlorinated and polybrominated biphenyl isomers and congeners. Cy...

Capecitabine, a fluoropyrimidine prodrug, has been a frequently chosen ligand for the last one and half decades to inhibit thymidylate synthase (TYMS) for treatment of colorectal cancer. TYMS is a key enzyme for de novo synthesis of deoxythymidine monophosphate and subsequent synthesis of DNA. Recent years have also seen the trait of modifying ligands using halogens and trifluoromethyl (-CF3) g...

Background: Antibiotics with β-Lactam rings (β-Lactams), since they were discovered, have enhanced the typical treatment for bacterial infections. Though their resistance can quickly spread on a universal scale, is primarily caused by production of β-lactamases. Hence, there serious demand to design and create new anti-β-lactamases or inhibitors. Nowadays, use β-lactamase inhibitors β-lactams r...

Halogenated oligosilanes and oligogermanes are interesting compounds in oligosilane chemistry from the viewpoint of silicon-based-materials. Herein, it was demonstrated that a 1,2-digermacyclobutadiene derivative could work as a bis-germylene building block towards double Si–Cl activation to give a halogenated oligometallane, a bis(chlorogermyl)dichlorosilane derivative.