21 The neuromodulator acetylcholine shapes neocortical function during sensory 22 perception, motor control, arousal, attention, learning and memory. Here we investigate 23 the mechanisms by which ACh affects neocortical pyramidal neurons in adult mice. 24 Stimulation of cholinergic axons activated muscarinic and nicotinic ACh receptors on 25 pyramidal neurons in all cortical layers and in mult...