The bacterial potassium channel KcsA is gated open by the binding of protons to amino acids on the intracellular side of the channel. We have identified, via channel mutagenesis and x-ray crystallography, two pH-sensing amino acids and a set of nearby residues involved in molecular interactions that influence gating. We found that the minimal mutation of one histidine (H25) and one glutamate (E...

Összefoglaló. Egy 47 éves nőbeteg tranziens ST-eleváció miatt került felvételre és coronarographiára. A ST-elevációnak véleményezett elektrokardiogram poroszsisak-jelnek felelt meg, amelyet egy EKG-műtermék okozott. Habár a számtalan, nem coronariaeredetű oka ismert, műtermék okozta poroszsisak-jelet még ismertettek. Fontos felismerése felesleges diagnosztikai terápiás beavatkozások elkerülése ...

The seniority of employees’ claims in the liquidation of insolvent firms, and their rights in the renegotiation of their debt varies greatly across countries. Using a simple model of strategic leverage, we show that the balance between these rights of employees and those of other creditors affects the strategic value of debt: in equilibrium, stronger employees’ seniority rights in bankruptcy li...

Knowledge Graphs have emerged as a compelling abstraction for capturing key relationship among the entities of interest to enterprises and integrating data from heterogeneous sources. JPMorgan Chase (JPMC) is leading this trend by leveraging knowledge graphs across organization multiple mission critical applications such risk assessment, fraud detection, investment advice, etc. A core problem i...

This paper examines the effect of value-added taxes (VATs) on international trade. Destination-based VATs are commonly thought to encourage exports, since exports are exempt from tax while imports are taxed. Economic theory implies that exchange rate adjustment prevents destination-based VATs from affecting exports and imports, since exchange rate appreciation completely undoes the effects of i...

a r t i c l e i n f o JEL classification: C53 G17 Keywords: GARCH Higher conditional moments Approximate predictive distributions Value-at-Risk S&P 500 Treasury bill rate Euro–US dollar exchange rate It is widely accepted that some of the most accurate Value-at-Risk (VaR) estimates are based on an appropriately specified GARCH process. But when the forecast horizon is greater than the frequency...