Pre-existing immunity is an important factor countering the pandemic potential of an emerging influenza virus strain. Thus, studying of pre-existing immunity to the 2009 pandemic H1N1 virus (2009 H1N1) will advance our understanding of the pathogenesis and epidemiology of this emerging pathogen. In the present study, sera were collected from 486 individuals in a hospital in Shanghai, China, bef...

1. Centers for Diseases Control and Prevention. Updated interim recommendations: special considerations for clinicians regarding 2009 H1N1 influenza in severely immunosuppresed patients (on line). [Acessed on 2010 Sept 13]. Available from: http://www.cdc.gov/h1n1flu/immunosuppresion/ 2. Bacal F, Seguro LF, Ogawa T, Mangini S, Fiorelli AI, Bocchi E. Pneumonia por influenza A (H1N1) em paciente i...

the serious influenza-associated complications among immunodeficient individuals such as those who are infected with human immunodeficiency virus (hiv), highlights the importance of influenza vaccination in these people. therefore, the current study aimed to investigate the antibody responses to influenza vaccine in this group. two hundred subjects were recruited, during autumn 2010 and 2011, t...

conclusions the prevalence of pandemic influenza viruses in recent years has caused financial losses as well as mortalities around the world. this shows the importance of the rapid diagnosis of common serotypes in our society. using real-time rt-pcr is recommended for the early diagnosis and the rapid identification of the individuals infected with pandemic influenza virus. background timely di...

UNLABELLED We have previously shown that 11 patients became naturally coinfected with seasonal H1N1 (A/H1N1) and pandemic H1N1 (pdm/H1N1) during the Southern hemisphere winter of 2009 in New Zealand. Reassortment of influenza A viruses is readily observed during coinfection of host animals and in vitro; however, reports of reassortment occurring naturally in humans are rare. Using clinical spec...

MicroRNAs have been implicated in the regulation of gene expression of various biological processes in a post-transcriptional manner under physiological and pathological conditions including host responses to viral infections. The 2009 pandemic H1N1 influenza virus is an emerging reassortant strain of swine, human and bird influenza virus that can cause mild to severe illness and even death. To...

BACKGROUND Influenza infections may result in different clinical presentations. This study aims to determine the clinical differences between circulating influenza strains in a young healthy adult population in the tropics. METHODS A febrile respiratory illness (FRI) (fever ≥ 37.5°C with cough and/or sore throat) surveillance program was started in 4 large military camps in Singapore on May 2...

OBJECTIVE To determine virologic and epidemiologic characteristics of pandemic (H1N1) 2009 at All India Institute of Medical Sciences (AIIMS) a tertiary care hospital in New Delhi, India. METHODS Nasal and throat swabs from patients with febrile acute respiratory illness (FARI) from August to December 2009 (n = 1401) were tested for 2009A/H1N1 and seasonal influenza A viruses by real-time RT-...

BACKGROUND Limited data are available describing the clinical presentation and risk factors for admission to the intensive care unit for children with 2009 H1N1 infection. METHODS We conducted a retrospective chart review of all hospitalized children with 2009 influenza A (H1N1) and 2008-09 seasonal influenza at The Children's Hospital, Denver, Colorado. RESULTS Of the 307 children identifi...

This report summarizes influenza activity in the United States during November 26, 2000-January 13, 2001. Influenza activity was low to moderate but increasing in the United States. Since October 1, the most frequently isolated viruses were influenza A (H1N1) and were well matched antigenically with the 2000-01 influenza A (H1N1) vaccine strain.