Considerable variation in composition occurs among samples of ribonucleic acids from yeast. These variations are due in part to the procedures that are employed for isolation and subsequent purification. A recent study by Loring, Fairley, and Seagran (1) notes that variations may be due to (a) the occurrence of different ribonucleic acids in the particulate components of cells, (b) partial enzy...

Crambescidins and batzelladines, novel marine guanidine alkaloids, have unique pentacyclic and tricyclic guanidine core structures, respectively. They display a considerable array of biological activity and not surprisingly have attracted considerable synthetic interest. The first total synthesis of crambescidin 359 (7) and stereoselective total synthesis of batzelladine D (11) were accomplishe...

A pragmatic approach has been developed for the estimation of aqueous ionization constants (pKa) for druglike compounds. The method involves an algorithm that assigns ionization constants in a stepwise manner to the acidic and basic groups present in a compound. Predictions are made for each ionizable group using models derived from semiempirical quantum chemical properties and information-base...

The non-specific analytical methods for the guanidinium compounds in biological fluids have been unsatisfactory for many years. The methods presented in this paper have a greatly improved specificity and are not too complex for use in the clinical laboratory. A modified Sakaguchi color reaction for substituted guanidines is used in each procedure. Guanidinoacetic acid is measured by developing ...

A set of trisubstituted guanidine ligands L1H2–L4H2 with general formula (iPrHN)2CNR (R = Ph (L1H2), R 2,4,6-Me3C6H2(L2H2), p-BrC6H4(L3H2), (C5H4)Fe(C5H5), Fc (L4H2)) was employed to synthesize a family mono- and dinuclear asymmetric methyl aluminum guanidinato compounds ((L2H)AlMe2 (1), (L4H)AlMe2 (2), (L1)Al2Me4 (3), (L2)Al2Me4 (4), (L3)Al2Me4 (5), (L4)Al2Me4 (6), (L1H)2AlMe (7), (L2H)2AlMe (...

Functionalized acyclic and cyclic guanidines have a wide range of biological activity. In particular, they possess antitumor, antibacterial activities, are immunosuppressants, anesthetics, analgesics analogues natural alkaloids. The search methods for the synthesis new guanidine derivatives is an urgent problem.
 introduction unsaturated alkyl substituent to backbone opens way heterocyclic...

Recently two novel enzymes were identified in the outer mitochondrial membrane, mARC1 and mARC2. These molybdenum containing enzymes can reduce a variety of N-hydroxylated compounds, such as N-hydroxy-guanidines and sulfohydroxamic acids, as well as convert nitrite into nitric oxide (NO). However, their endogenous functions remain unknown. Here we demonstrate a specific developmental pattern of...