BACKGROUND Guaifenesin (glyceryl guaiacolate ether [GGE]) has been studied as a cough suppressant and as an expectorant; however, published studies to date have failed to find a consistent benefit. METHODS An 8-day multi-center clinical trial was conducted to study the effect of two 600-mg extended-release GGE tablets twice daily for 1 week on cold symptoms, sputum volume, and properties in a...

In health, the airways are lined by a layer of protective mucus gel that sits atop a watery periciliary fluid. Mucus is an adhesive, viscoelastic gel, the biophysical properties of which are largely determined by entanglements of long polymeric gel-forming mucins, MUC5AC and MUC5B. This layer entraps and clears bacteria and inhibits bacterial growth and biofilm formation. It also protects the a...

BACKGROUND Acute bacterial rhinosinusitis (ABRS) is a common illness that is routinely managed by physicians from several different specialties. However, the actual diagnostic and treatment preferences of physicians from these different specialties are not known. OBJECTIVE To determine whether the radiographic evaluation and management of community-acquired ABRS differs according to medical s...

METHODS Using a telephone survey of 434 women who self-reported having and 198 women, who denied having fibromyalgia (FM) (aged 18-80 years), we compared women on self-reported number, major types, and effectiveness of currently taken conventional medications and herbs/supplements. RESULTS Ninety-three percent of women with FM reported taking at least one medication (1855 total, 499 types, on...

OBJECTIVE Pediatric cough and cold medications are widely marketed in the United States, but the precise patterns of use among children are not known. Such information is especially important given recent reports suggesting that these medications are responsible for previously underappreciated serious adverse events and deaths among children. We sought to describe the prevalence and patterns of...

Jedes Jahr müssen tausende defekte Herzklappen ersetzt werden. Die Verwendung von biologischen oder mechanischen Prothesen macht aufgrund der Tatsache, dass diese nicht mitwachsen, gerade bei Heranwachsenden regelmäßige Reimplantationen erforderlich. Eine mögliche Alternative sind Klappenprothesen bestehend aus einer Gerüststruktur, welche mit körpereigenen Zellen besiedelt wird. Das Gerüst wir...

If Dark Matter is made of Weakly Interacting Massive Particles (WIMPs) with masses below [Formula: see text] GeV, the corresponding nuclear recoils in mainstream WIMP experiments are of energies too close, or below, the experimental threshold. Gas Time Projection Chambers (TPCs) can be operated with a variety of target elements, offer good tracking capabilities and, on account of the amplificat...