نتایج جستجو برای: gsk 3β

تعداد نتایج: 7293  

Journal: :Advanced pharmaceutical bulletin 2015
Reza Badalzadeh Mustafa Mohammadi Bahman Yousefi Safar Farajnia Moslem Najafi Shima Mohammadi

PURPOSE Diabetes mellitus as a main risk-factor of ischemic heart disease may interfere with postconditioning'scardioprotective effects. This study aimed to investigate the involvement of glycogen synthase kinase-3β (GSK-3β) and oxidation status in chronic diabetes-induced loss of cardioprotective effect of ischemic-postconditioning (IPostC) in Wistar rats. METHODS After 8 weeks of induction ...

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2011
Nicole L Yohn Caitlyn N Bingaman Ashley L DuMont Lina I Yoo

BACKGROUND The PTEN/Phosphatidylinositol 3'-kinase (PI3-kinase) growth factor signaling pathway plays a critical role in epithelial tumor development in a multitude of tissue types. Deletion of the Pten tumor suppressor gene in murine urothelial cells in vivo results in upregulation of cyclin-dependent kinase inhibitor p21. We have previously shown in mice that p21 expression blocks an increase...

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2014
Marianeve Carotenuto Pasqualino De Antonellis Lucia Liguori Giovanna Benvenuto Daniela Magliulo Alessandro Alonzi Cecilia Turino Carmela Attanasio Valentina Damiani Anna Maria Bello Fabiana Vitiello Rosa Pasquinelli Luigi Terracciano Antonella Federico Alfredo Fusco Jamie Freeman Trevor C. Dale Charles Decraene Gennaro Chiappetta Francovito Piantedosi Cecilia Calabrese Massimo Zollo

H-Prune hydrolyzes short-chain polyphosphates (PPase activity) together with an hitherto cAMP-phosphodiesterase (PDE), the latest influencing different human cancers by its overexpression. H-Prune promotes cell migration in cooperation with glycogen synthase kinase-3 (Gsk-3β). Gsk-3β is a negative regulator of canonical WNT/β-catenin signaling. Here, we investigate the role of Gsk-3β/h-Prune co...

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Journal: :American journal of translational research 2017
Chunxia Zhou Jie Bai Chuan Jiang Lincai Ye Yanjun Pan Haibo Zhang

Early reperfusion of myocardial infarction area is the most effective and important therapy to acute myocardial infarction, but could induce reperfusion injury. Geranylgeranylacetone (GGA), an acyclic polyisoprenoid used as an oral anti-ulcer medication, has been reported to have protective effects on reperfusion injury. In the present study, we explored the protective effect of GGA against MIR...

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2015
Jianqiong Yang Haiqing Liu Linfu Li Hai Liu Weimei Shi Longhuo Wu

Endoplasmic reticulum stress (ERS) has been demonstrated to exhibit a critical role in osteoarthritic chondrocytes. Whether 5,7,3',4'-tetramethoxyflavone (TMF) plays the chondroprotective role in inhibition of PGE2-induced chondrocytes apoptosis associating with ERS has not been reported. To investigate this, the activation of PERK, ATF6, and IRE1 signaling pathways in ERS in chondrocytes pretr...

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2014
Hong Zhang Wei Hou Hua-Li Wang Hai-Jing Liu Xin-Ying Jia Xing-Zheng Zheng Yong-Xin Zou Xin Li Lin Hou Michael A McNutt Bo Zhang

Purpose: NAT10 (N-acetyltransferase 10) is a nucleolar protein, but may show subcellular redistribution in colorectal carcinoma (CRC). In this study, we evaluated membranous staining of NAT10 in colorectal carcinoma and its clinical implications, and explored the mechanism of regulation of NAT10 redistribution. Experimental Design: The expression and subcellular redistribution of NAT10, β-caten...

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2010
Jay Graham Michael Fray Stephanie de Haseth Kang Mi Lee Moh-Moh Lian Catharine M. Chase Joren C. Madsen James Markmann Gilles Benichou Robert B. Colvin A. Benedict Cosimi Shaoping Deng James Kim Alessandro Alessandrini

The mechanism by which regulatory T cells (Tregs) suppress the immune response is not well defined. A recent study has shown that β catenin prolongs Treg survival. Since β-catenin is regulated by GSK-3β directed phosphorylation, we focused on GSK-3β and the role it plays in Treg function. Inhibition of GSK-3β leads to increased suppression activity by Tregs. Inhibitor-treated Tregs exhibited pr...

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2016
Yan-Juan Wang Qing-Guo Ren Wei-Gang Gong Di Wu Xiang Tang Xiao-Li Li Fang-Fang Wu Feng Bai Lin Xu Zhi-Jun Zhang

Tau hyperphosphorylation is an important pathological feature of Alzheimer's disease (AD). To investigate whether escitalopram could inhibit amyloid-β (Aβ)-induced tau hyperphosphorylation and the underlying mechanisms, we treated the rat primary hippocampal neurons with Aβ1-42 and examined the effect of escitalopram on tau hyperphosphorylation. Results showed that escitalopram decreased Aβ1-42...

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2016
Anwen Wei Bo Fan Yujie Zhao Han Zhang Liping Wang Xiao Yu Qingmin Yuan Deyong Yang Shujing Wang

ST6Gal-I sialyltransferase adds α2,6-linked sialic acids to the terminal ends of glycan chains of glycoproteins and glycolipids. ST6Gal-I is reportedly upregulated in many cancers, including hepatocellular carcinoma, ovarian cancer and breast cancer. However, the expression and function of ST6Gal-I in prostate cancer (PCa) and the mechanism underlying this function remain largely unknown. In th...

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2017
Fei Wu Jun Chen Li-Mei Fan Kai Liu Ning Zhang Shi-Wen Li He Zhu Hai-Cheng Gao

The aim of the present study was to investigate the effect of rutin treatment on the expression of glycogen synthase kinase (GSK)-3β and tumor necrosis factor (TNF)-α in A549 human lung carcinoma cells. The A549 cells were divided into control, cisplatin and rutin (low, middle and high) groups. ELISA and western blot analysis of TNF-α expression, 4',6-diamino-2-phenylindole (DAPI) staining and ...

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