OF COMMUNICATION ON THE USE OF POST PART.UM BINDERS. By Dr Thomas Cairns.

In the String & Binders Switch (SBS) model 1,2 a chromatin filament is represented as a self-avoiding (SAW) polymer chain, composed by N beads. Each bead of the chain interacts with diffusing Brownian particles (binders) having a molar concentration c. The scale of their binding energy to a cognate polymer bead is named í µí°¸!"#. The beads of the chain and the binders are subject to Brownian m...

Field ageing is investigated based on recovered binders. Fifteen sections were considered, consisting of unmodified and polymer-modified binders (PmB). Binders from the wearing course, after slicing cores horizontally. To assess field laboratory tendencies, compared to a set reference binders, tested before ageing. For three sites, bottom slices long-term aged properties top slices. Stiffness-b...

Computational prediction of protein function is frequently error-prone and incomplete. In Mycobacterium tuberculosis (Mtb), ~25% of all genes have no predicted function and are annotated as hypothetical proteins, severely limiting our understanding of Mtb pathogenicity. Here, we utilize a high-throughput quantitative activity-based protein profiling (ABPP) platform to probe, annotate, and valid...

Nominal rewriting introduced a novel method of specifying rewriting on syntax-with-binding. We extend this treatment of rewriting with hierarchy of variables representing increasingly ‘meta-level’ variables, e.g. in hierarchical nominal term rewriting the meta-level unknowns (representing unknown terms) in a rewrite rule can be ‘folded into’ the syntax itself (and rewritten). To the extent that...

Ribosome display has proven to be a powerful in vitro selection and evolution method for generating high-affinity binders from libraries of folded proteins. It has been successfully applied to single-chain Fv fragments of antibodies and alternative scaffolds, such as Designed Ankyrin Repeat Proteins (DARPins). High-affinity binders with new target specificity can be obtained from highly diverse...

HEALTH POLITICAL BACKGROUND In 2006, the prevalence of chronic renal insufficiency in Germany was 91,718, of which 66,508 patients were on dialysis. The tendency is clearly growing. SCIENTIFIC BACKGROUND Chronic renal insufficiency results in a disturbance of the mineral balance. It leads to hyperphosphataemia, which is the strongest independent risk factor for mortality in renal patients. Us...

The paper proposes a novel, integrated approach to the identification and quantification of the organic binders, mainly proteinaceous, as the “invisible” component of polychrome layers in artifacts belonging to movable and immovable cultural heritage. The analytical methodology discussed here will demonstrate the significance and efficiency of biochemical assays for the detection of organic bin...

Ever since the introduction of nitrocellulose (NC) as an explosive fill in the 1850s, polymers have contributed considerably to advancements in the technology of both propellants and explosives. In addition to the specific instance of the use of NC polymer in explosive fills, applications of polymers have been most extensive in binders andplasticizers.Over the years,with thematurity of composit...

The enhanced analytical performances of immunoassays that employed site-directly immobilized antibodies as the capture binders have been functionally characterized in terms of antigen-antibody complex formation on solid surfaces. Three antibody species specific to cardiac troponin I, immunoglobulin G (IgG), Fab, and F(ab')(2) were site-directly biotinylated within the hinge region and then immo...