In previous studies, we have shown the relaxatory effect of grape leaf (Vitis vinifera) extract on isolated ileum, uterus and aorta. In rat aorta it was revealed that the NO and endothelium are involved in the relaxation induced by grape leaf extract. The aim of present study was to investigate the effect of the Vitis vinifera leaf hydroalcoholic extract (VLHE) on rat trachea precontracted by A...

Background: Fluoxetine (FLX) is a selective serotonin reuptake inhibitors antidepressant. FLX affects chemicals in the brain that may become unbalanced and cause depression, panic, anxiety, or obsessive-compulsive symptoms. Black Grape seed extract (BGSE) antioxidants neutralize free radicals and oxidative stress. Therefore this study was designed to investigate Protective effect of RGSE hydroa...

Tannins, polyphenolic compounds found in plants, are known to complex with proteins of feed and rumen bacteria. This group of substances has the potential to reduce methane production either with or without negative effects on digestibility and microbial yield. In the first step of this study, 10 tannin-rich extracts from chestnut, mimosa, myrabolan, quebracho, sumach, tara, valonea, oak, cocoa...

Ionizing radiation (IR) has become an integral part of the modern medicine--both for diagnosis as well as therapy. However, normal tissues or even distant cells also suffer IR-induced free radical insult. It may be more damaging in longer term than direct radiation exposure. Antioxidants provide protection against IR-induced damage. Grapes are the richest source of antioxidants. Here, we assess...

UNLABELLED Dental caries is considered a disease of high prevalence and a constant problem in public health. Proanthocyanidins (PAs) are substances that have been the target of recent studies aiming to control or treat caries. OBJECTIVE The aim of this in vitro study was to evaluate the efficacy of a treatment with grape seed extract, under cariogenic challenge, to minimize or even prevent th...

Background: Cylophosphamide is used alone or in combination with other drugs for treatment of neoplastic diseases. Hemorrhagic cystitis is a major potential toxicity and dose limiting side effect of cyclophosphamide. The aim of this study was to evaluate the effects of lycopene compared with some antioxidants for the prevention of cyclophosphamide induced hemorrhagic cystitis in rats. Methods: ...

BACKGROUND The objective of this in-vitro study was to evaluate the effect of grape seed extract (oligomericproanthocyanidin complexes [OPCs]) on the bond strength of composite resin to bleached enamel using 5th and 7th generations of bonding agents. MATERIALS & METHODS Eighty maxillary central incisors were randomly assigned to four groups as follows: Group I (n=20): no bleaching (control); ...

BACKGROUND Grape and blueberry extracts are known to protect against age-related cognitive decline. However, beneficial effects achieved by mixing grape and blueberry extracts have yet to be evaluated in dogs, or their bioavailability assessed. Of concern to us were cases of acute renal failure in dogs, after their ingestion of grapes or raisins. The European Pet Food Industry Federation (2013)...

The effects of natural extracts on the formation of polar (IQ, MeIQ, MeIQx, 4,8-DiMeIQx, and PhIP) and nonpolar (norharman, harman, and A C) heterocyclic amines (HAs) were examined in ground beef cooked at 200 and 210°C for 20 min. In experiment 1, the formation of MeIQx was effectively reduced by 77%, 75%, and 69%, respectively, for 1.0% pine bark extract (Pycnogenol), 1.0% Oleoresin rosemary ...