نتایج جستجو برای: granzyme h
تعداد نتایج: 533304 فیلتر نتایج به سال:
Circulation Research is available at http://circres.ahajournals.org DOI: 10.1161/CIRCRESAHA.116.304734 Rationale: CD4+ natural killer T (NKT) cells augment atherosclerosis in apolipoprotein E–deficient (ApoE)−/− mice but their mechanisms of action are unknown. Objectives: We investigated the roles of bystander T, B, and NK cells; NKT cell–derived interferon-γ, interleukin (IL)-4, and IL-21 cyto...
BACKGROUND Pro-inflammatory/cytotoxic T cells (IFNγ, TNFα, granzyme B+) are increased in the peripheral circulation in COPD. NKT-like and NK cells are effector lymphocytes that we have also shown to be major sources of pro-inflammatory cytokines and granzymes. P-glycoprotein 1 (Pgp1) is a transmembrane efflux pump well characterised in drug resistant cancer cells. We hypothesized that Pgp1 woul...
In tumor cells, the serine protease granzyme B is the primary mediator of apoptosis induced by cytotoxic T lymphocytes (CTLs)/natural killer (NK) cells. The human intracellular serpin proteinase inhibitor 9 (PI9) is the only known human protein able to inhibit the proteolytic activity of granzyme B. When present in the cytoplasm of T lymphocytes, PI9 is thought to protect CTLs against apoptosis...
Background: The most common histologic type of cervical cancer is squamous cell carcinoma (SCC), with the risk recurrence depending on immune surveillance granzyme-B markers, and tumor infiltrating lymphocytes (TIL) an immunological determinant associated a better prognosis. Granzyme-B produced by TIL. study was aimed to prove difference in expression SCC epithelial cells dysplasia precancerous...
نمودار تعداد نتایج جستجو در هر سال
با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید