The orofacial pain clinician must understand the difference between peripheral and central mechanisms of pain. Particularly, one has to understand the process of central sensitization as it relates to the various orofacial pain conditions to understand orofacial pain. Understanding leads to more effective treatment.

Polyangiitis with granulomatosis, previously known as Wegener's granulomatosis, is a systemic necrotising granulomatous vasculitis. It predominantly affects the upper and lower respiratory tracts and the kidneys, but can potentially affect any organ system. It is diagnosed by clinical features, immunology (anti-neutrophil cytoplasmic antibodies) and histology. Cardiac involvement occurs in 6 to...

BACKGROUND Clefts of the lip (CL), the palate (CP), or both (CLP) are the most common orofacial congenital malformations found among live births, accounting for 65% of all head and neck anomalies. The frequency and pattern of orofacial clefts in different parts of the world and among different human groups varies widely. Generally, populations of Asian or Native American origin have the highest...

vasculitides are a heterogeneous group of more than 20 diseases defined by inflammation and destruction of blood vessels. we aimed to study the demographic characteristics of the primary vasculitides in the north east of iran. we retrospectively studied the medical records of patients diagnosed with any kind of vasculitis at the clinic and department of rheumatology of the imam reza hospital, m...

BACKGROUND Hyperexcitability of nociceptive afferent fibers is an underlying mechanism of neuropathic pain and ion channels involved in neuronal excitability are potentially therapeutic targets. KCNQ channels, a subfamily of voltage-gated K(+) channels mediating M-currents, play a key role in neuronal excitability. It is unknown whether KCNQ channels are involved in the excitability of nocicept...

Objectives : To determine the impact of orofacial clefts on the oral health-related quality of life of affected children and whether the oral health-related quality of life of children with orofacial clefts differs among different age groups. To assess whether the responses of children with orofacial clefts differ from the caregivers' perceptions of their child's oral health-related quality of ...

BACKGROUND Open bite is a complex anomaly that has a difficult treatment. Frequently, unsatisfactory results and relapse of orthodontic treatment are observed. AIM To associate orofacial malfunction and deleterious oral habits to anterior open bite. To congregate evidences for the better understanding of the etiology and of the development of anterior open bite and its potential association t...

Orofacial clefts are the commonest congenital structural anomalies of the lip and/or palate. Beyond cosmetic abnormality children often suffer from feeding difficulties, ear infections, hearing loss, speech and language delay, dental problems and multiple craniofacial/dental surgeries. Present study was conducted to assess DNA damage among children with orofacial clefts. One ml of peripheral bl...

Orofacial clefts are among the most common birth defects and result in an improper formation of the mouth or the roof of the mouth. Monosomy of the distal aspect of human chromosome 6p has been recognized as causative in congenital malformations affecting the brain and cranial skeleton including orofacial clefts. Among the genes located in this region is PAK1IP1, which encodes a nucleolar facto...

Headache associated with cervical lesions is called cervicogenic headache and involves the occiput but not the orofacial region. However, patients occasionally present with orofacial pain accompanied by neck symptoms. This study investigates whether orofacial pain can originate from the neck and whether cervical plexus block can help in diagnosis. We enrolled eight patients suffering from chron...